文献类型：期刊文献

英文题名：Characteristics of oral microbiota in plateau and plain youth-positive correlations between blood lipid level, metabolism and specific microflora in the plateau group

作者：Zhao, LiBo[1,2];Wang, Huanhuan[3];Gao, Yinghui[4];Hao, Benchuan[1,2];Li, Xueyan[5];Wen, Ruoqing[6];Chen, Kaibing[7];Fan, Li[1,2];Liu, Lin[1,8]

第一作者：Zhao, LiBo

通信作者：Fan, L[1];Liu, L[1];Chen, KB[2];Liu, L[3]

机构：[1]Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China;[2]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Cardiol Dept, Beijing, Peoples R China;[3]Peking Univ, Coll Nursing, Beijing, Peoples R China;[4]Peking Univ Int Hosp, Sleep Ctr, Beijing, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[6]Gansu Univ Tradit Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[7]Gansu Univ Tradit Chinese Med, Sleep Ctr, Affiliated Hosp, Lanzhou, Peoples R China;[8]Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Med Ctr 2, Beijing, Peoples R China

第一机构：Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China

通信机构：[1]corresponding author), Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Sleep Ctr, Affiliated Hosp, Lanzhou, Peoples R China;[3]corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Med Ctr 2, Beijing, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2022

卷号：12

外文期刊名：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85136787171);WOS:【SCI-EXPANDED(收录号:WOS:000890922000001)】；

基金：This study was supported by Youth Program for Military Medicine of Chinese PLA General Hospital (QNC19054), Military Health Care Project (19BJZ34), and Military Equipment Construction Application Research Project (LB20211A010013). The funders had no direct role in the design, data collection, analysis, interpretation, or writing of the manuscript.

语种：英文

外文关键词：oral microbiota; high-throughput sequencing; biodiversity; altitude; relative abundance; metabolic function; triglyceride

摘要：ObjectivesTo analyze the characteristics of oral microbiota in plateau and plain youth and the possible function of the microbiome. Materials and methodsA total of 120 healthy young males (80 on the plateau, 40 on the plain) completed this cross-sectional study. Oral microflora samples were collected from all participants. The bacterial 16S rDNA was amplified using PCR and sequenced using Illumina MiSeq high-throughput sequencing. The data were analyzed to determine the microbial distribution and community structure of the oral microflora from the two groups. Metastats was used to test differences in relative species abundance between the groups. The correlation between the abundance of specific bacteria and blood indicators was also analyzed. ResultsAs demonstrated by alpha and beta diversity, the plateau group had lower microbial richness and a less even distribution of oral microbiota than the plain group. All predominant phyla and genera were qualitatively similar between the two groups, but their relative abundances differed. The relative abundance of bacteria in the phylum Firmicutes was significantly higher in the plateau group than in the plain group. At the genus level, Streptococcus spp. and Gemella spp. were also more abundant in the plateau group. The functional prediction indicated vigorous microbial metabolism in the oral bacterial community. We also found that the relative abundance of Streptococcus spp., the dominant genus, was positively correlated with triglyceride levels in the plateau group. ConclusionsWith increasing altitude, the diversity of oral microbiota and the relative proportion of predominant bacteria were altered. The distribution and related function of Streptococcus spp. were prominent in plateau samples. This comprehensive study of the relationship between oral microecology and elevation provides a point of reference for studying the human body's adaptability or inadaptability to high altitude.