文献类型：期刊文献

中文题名：藏药唐古特乌头总生物碱的急性毒性及抗炎镇痛作用

英文题名：Acute Toxicityand Anti-inflammatoryor Analgesic Effects of Total Alkaloids of Aconitum Tanguticum in Mice

作者：吴国泰[1,2];牛亭惠[1];刘五州[1];王瑞琼[1];杜丽东[1,2];李广远[1]

第一作者：吴国泰

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2017

卷号：26

期号：10

起止页码：28

中文期刊名：中国民族民间医药

外文期刊名：Chinese Journal of Ethnomedicine and Ethnopharmacy

基金：西藏自治区重大专项(No.2013KJGX01-30);甘肃省中药药理与毒理学重点实验室开放基金(No.ZDSYS-KJ-2012-004)

语种：中文

中文关键词：唐古特乌头;生物碱;急性毒性;抗炎镇痛

外文关键词：Aconitum tanguticum （Maxim） stapf; Alkaloids; Acute Toxicity; Anti -inflammatory and Analgesic Effect

摘要：目的:研究藏药唐古特乌头总生物碱(TAA)的急性毒性及抗炎镇痛作用。方法:采用灌胃和腹腔注射两种给药途径研究TAA的急性毒性;采用二甲苯致小鼠耳肿胀、琼脂肉芽肿两种炎症模型,考察TAA的抗炎作用;采用冰醋酸致小鼠扭体和热板致痛两种疼痛模型,观察TAA的镇痛作用。结果:TAA具有一定急性毒性,对二甲苯致小鼠耳肿胀和皮下琼脂肉芽肿两种炎症模型以及冰醋酸致小鼠扭体和热板致痛两种疼痛模型均有一定的抑制作用。结论:藏药唐古特乌头总生物碱具有抗炎镇痛作用,也具有一定的急性毒性。
Objective To study the acute toxicityand anti - inflammatoryor analgesic effectsoftotal alkaloids of Aconitum tanguticum （Maxim） stapf （TAA） through experiments. Methods Acute toxicity of TAA were measured by using oral and intraperitoneal injec- tion of routes of administration. The anti - inflammatory effects of TAA were observed by using the test of mouse ear swelling induced by xylene and the weight of placing agar into subcutaneous of mouse to induce granuloma. The analgesic effects of TAA were observed by using the test of mouse twister induced by glacial acetic acid and the test of ache induced by hot were set up. Results TAA have in- hibitory effect to both of the inflammatory models and ache models. TAA has some acute toxicity. Conclusion TAA had anti - inflam- matory and analgesic effects, andacute toxicity was appreciated.