文献类型：期刊文献

英文题名：Transitioning from molecular methods to therapeutic methods: An in-depth analysis of glioblastoma (Review)

作者：Han, Hongxi[1];Du, Aichao[1];Li, Jinwen[2];Han, Hongyan[3];Feng, Peng[1];Zhu, Yufeng[1];Li, Xinlong[1];Tian, Guopeng[1];Yu, Haijia[1];Zhang, Bo[1];Liu, Weiguo[4];Yuan, Guoqiang[1]

第一作者：Han, Hongxi

通信作者：Yuan, GQ[1]

机构：[1]Lanzhou Univ, Hosp 2, Dept Neurosurg, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Inst Integrat Med, Lanzhou 730000, Gansu, Peoples R China;[3]Tianshui First Peoples Hosp, Dept Neurol, Tianshui 741000, Gansu, Peoples R China;[4]Lanzhou Univ Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Dept Neurosurg, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 2, Dept Neurosurg, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China.

年份：2025

卷号：53

期号：4

外文期刊名：ONCOLOGY REPORTS

收录：;Scopus(收录号：2-s2.0-86000080965);WOS:【SCI-EXPANDED(收录号:WOS:001442157800001)】；

基金：Not applicable.

语种：英文

外文关键词：glioblastoma; molecular mechanism; signaling pathway; therapy; assessment

摘要：Glioblastoma (GBM) is the most aggressive primary brain tumour, characterised by high heterogeneity, aggressiveness and resistance to conventional therapies, leading to poor prognosis for patients. In recent years, with the rapid development of molecular biology and genomics technologies, significant progress has been made in understanding the molecular mechanisms of GBM. This has revealed a complex molecular network involving aberrant key signalling pathways, epigenetic alterations, interactions in the tumour microenvironment and regulation of non-coding RNAs. Based on these molecular features, novel therapeutic strategies such as targeted therapies, immunotherapy and gene therapy are rapidly evolving and hold promise for improving the outcome of GBM. This review systematically summarises the advances in molecular mechanisms and therapeutic approaches for GBM. It aims to provide new perspectives for the precise diagnosis and personalised treatment of GBM, and to ultimately improve the prognosis of patients.