文献类型：期刊文献

英文题名：Effect of Zibushenjing Fang on skeletal development and brain tissue antioxidation in mice with kidney essence insufficiency: a mechanistic study

作者：He, Yuezhen[1];Yao, Junxiao[2];Shen, Shilin[1];Su, Xiaojun[3];Wang, Yuping[1];Li, Li[1];Wang, Wenhui[1];Shi, Jiping[1]

第一作者：He, Yuezhen

通信作者：Shen, SL[1]

机构：[1]Lanzhou Univ, Affiliated Hosp 1, Dept Tradit Chinese Med & Intervent, Lanzhou 730000, Peoples R China;[2]Gansu Coll Tradit Chinese Med, Dept Acupuncture & Encephalopathy, Affiliated Hosp, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Orthoped, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Affiliated Hosp 1, Dept Tradit Chinese Med & Intervent, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Affiliated Hosp 1, Lanzhou 730000, Peoples R China.

年份：2013

卷号：33

期号：3

起止页码：394

外文期刊名：JOURNAL OF TRADITIONAL CHINESE MEDICINE

收录：;Scopus(收录号：2-s2.0-84880481229);WOS:【SCI-EXPANDED(收录号:WOS:000320425500021)】；

语种：英文

外文关键词：Deficiency of kidney essence; Antioxidants; Zibushenjing Fang

摘要：OBJECTIVE: To investigate the effects of Zibushenjing Fang (formula for tonifying the kidney essence) on skeletal development and brain tissue antioxidation in mice with kidney essence insufficiency. METHODS: Fifty male Kunming mice were randomly divided into five groups: normal group, model group, Jinkuishenqi Wan group, Zibushenjing Fang high dose group, and Zibushenjing Fang low dose group, with 10 mice in each group. The model of kidney essence insufficiency syndrome was established in all the mice except the normal group by using a cat to threaten the mice and by swimming until exhaustion daily which lasted about 21 days. Mice in the model group Were administered 20 mL/kg(-1).d(-1) of normal saline intragastrically. The Jinkuishenqi Wan group was given 2.7 g/kg(-1).d(-1) of a solution of Jinkuishenqi Wan. The Zibushenjing Fang high dose group was given 20 g/kg(-1).d(-1) and the Zibushenjing Fang low dose group was given 10 g/kg(-1).d(-1) of a solution of Zibushenjing Fang. The general condition of all the groups was observed, including the quantity of food and water intake, swimming time, length of femur, and weight of the femur and musculus quadriceps femoris. The total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and methane dicarboxylic aldehyde (MDA) activities in the brain tissues were detected. RESULTS: Zibushenjing Fang could improve the manifestation of kidney essence insufficiency, increase the quantity of food and water intake, swimming time, femur length, and femur and musculus quadriceps femoris weight. It could also regulate the activities of T-SOD, GSH-Px, and MDA in brain tissue. CONCLUSION: Zibushenjing Fang may play an important role in treating kidney essence insufficiency syndrome by promoting body development and improving brain tissue antioxidation. (C) 2013 JTCM. All rights reserved.