文献类型：期刊文献

中文题名：胺碘酮治疗急性心力衰竭并快速性心律失常的临床疗效

英文题名：Clinical effect of amiodarone in the treatment of acute heart failure complicated with tachyarrhythmia

作者：李静[1];陈燕[1];李雯[2];冯翠娟[3]

第一作者：李静

机构：[1]甘肃中医药大学第四附属医院(甘肃宝石花医院)药学部,兰州市730060;[2]甘肃中医药大学第四附属医院(甘肃宝石花医院)内科,兰州市730060;[3]甘肃卫生职业学院,兰州市730207

第一机构：甘肃中医药大学第二附属医院

年份：2023

卷号：16

期号：15

起止页码：5

中文期刊名：临床合理用药杂志

外文期刊名：Chinese Journal of Clinical Rational Drug Use

语种：中文

中文关键词：心力衰竭;快速性心律失常;胺碘酮;西地兰;治疗结果

外文关键词：Heart failure;Tachyarrhythmia;Amiodarone;Cedilanid;Treatment outcome

摘要：目的 观察胺碘酮治疗急性心力衰竭并快速性心律失常的临床疗效。方法 前瞻性纳入2017年1月—2022年1月于甘肃中医药大学第四附属医院治疗的急性心力衰竭并快速性心律失常患者120例,采用随机数字表法分为A组与B组,各60例。A组予以西地兰注射液,B组予以胺碘酮注射液。2组均用药24~48 h后评估疗效。比较2组临床疗效,用药前和用药后心功能指标、N末端脑钠肽前体(NT-proBNP)水平、平均动脉压、心率及不良反应。结果 B组治疗总有效率高于A组(95.00%vs. 78.33%,χ^(2)=7.212,P=0.007)。用药后,2组左心室射血分数(LVEF)高于用药前,左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、NT-proBNP水平、平均动脉压、心率低于用药前,且B组升高/降低幅度大于A组(P<0.05)。B组不良反应总发生率低于A组(8.33%vs. 26.67%,χ^(2)=6.984,P=0.008)。结论 胺碘酮用于急性心力衰竭并快速性心律失常患者能更有效地维持生命体征稳定,有效改善心功能,提高疗效,且治疗安全性较高。
Objective To observe the clinical effect of amiodarone in the treatment of acute heart failure complicated with tachyarrhythmia.Methods A total of 120 cases of acute heart failure patients complicated with tachyarrhythmia were perspectively selected from January 2017 to January 2022 in the Fourth Affiliated Hospital of Gansu University of Chinese Medicine,and they were divided into the A group and the B group by random number table method,60 cases in each group.Patients of the A group were given cedilanid injection,patients of the B group were given amiodarone injection,both groups were treated for 24-48 hours.Clinical effect,cardiac function indexes,NT-proBNP level,mean arterial pressure and heart rate before and after medication,and adverse reactions were compared between the two groups.Results Total effective rate of the B group was 95.00%,which was higher than 78.33%of the A group(χ^(2)=7.212,P=0.007).After medication,LVEF of the two groups was higher than that before medication,LVEDD,LVESD and NT-proBNP level,mean arterial pressure,heart rate were lower than those before medication,and the increase/decrease range of the B group was greater than that of the A group(P<0.05).Incidence of adverse reactions of the B group was 8.33%,which was lower than 26.67%of the A group(χ^(2)=6.984,P=0.008).Conclusion Amiodarone can more effectively maintain stable vital signs in the treatment of acute heart failure patients complicated with tachyarrhythmia,which can effectively improve cardiac function,promote clinical effect,and with higher safety.