文献类型：期刊文献

英文题名：Sperm telomere length as a novel biomarker of male infertility and embryonic development: A systematic review and meta-analysis

作者：Yuan, Yacheng[1,2];Tan, Yangyang[1,2];Qiu, Xiaolong[1,2];Luo, Hengfeng[1,2];Li, Yuxiang[1,2];Li, Ruijie[1,2];Yang, Xukai[2]

第一作者：Yuan, Yacheng

通信作者：Yang, XK[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]940 Hosp Joint Logist Support Force Chinese PLA, Dept Urol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), 940 Hosp Joint Logist Support Force Chinese PLA, Dept Urol, Lanzhou, Peoples R China.

年份：2023

卷号：13

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-85147013187);WOS:【SCI-EXPANDED(收录号:WOS:000922573500001)】；

基金：This study was supported by the Natural Science Foundation of Gansu Province (No. 18JR3RA405); Natural Science Foundation of Gansu Province (No. 21JR11RA008); and Innovation and Entrepreneurship Talent Project of Lanzhou (No. 2021-RC-106).

语种：英文

外文关键词：infertility; male; spermatozoa; telomere; embryos; diagnosis

摘要：Background: Telomeres have an essential role in maintaining the integrity and stability of the human chromosomal genome and preserving essential DNA biological functions. Several articles have been published on the association of STL with male semen parameters and clinical pregnancy. The results, however, are either inconclusive or inconsistent. Therefore, this meta-analysis aimed to systematically assess the accuracy and clinical value of sperm telomere length (STL) as a new marker for diagnosing male infertility and predicting the quality of embryonic development.Methods: We performed a comprehensive systematic search for relevant publications in PubMed, the Cochrane Library, Web of Science, Embase, Scopus, and Ovid, from database build to August 2022. All experimental studies exploring the association of STL with male semen quality, male infertility, or embryonic development were included.Results: Overall, Twelve prospective observational cohort studies (1700 patients) were eligible for inclusion in the meta-analysis. The meta-analysis showed a positive linear correlation between STL and semen parameters. The optimal cut-off value for STL diagnosing male infertility was 1.0, with a sensitivity and specificity of 80%. Regarding STL and embryonic development, the clinical pregnancy rate was associated with longer STL, and there was no significant difference between the two groups regarding fertilization rate.Conclusion: Our study showed that STL has good diagnostic and predictive value for male fertility and clinical pregnancy and could be used as a new biomarker for diagnosing male infertility and predicting embryonic development.