文献类型：期刊文献

英文题名：Liposomes: An Intelligent Drug Delivery System for Translational Applications in Bone Biomedicine

作者：Feng, Weike[1,2];Xue, Yun[1];Chang, Bin[1,2];Wang, Chunyang[1,2];Liu, Ruitang[1,2];Zhou, Yigui[1,2];Zhan, Longwen[1,2];Gao, Qiuming[1];Fan, Bo[1]

第一作者：Feng, Weike

通信作者：Gao, QM[1];Fan, B[1]

机构：[1]940 Hosp Joint Logist Support Force Chinese People, Orthoped Ctr Spine Surg, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China

第一机构：940 Hosp Joint Logist Support Force Chinese People, Orthoped Ctr Spine Surg, Lanzhou, Peoples R China

通信机构：[1]corresponding author), 940 Hosp Joint Logist Support Force Chinese People, Orthoped Ctr Spine Surg, Lanzhou, Peoples R China.

年份：2026

卷号：114

期号：5

外文期刊名：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

收录：;EI(收录号：20261820647629);Scopus(收录号：2-s2.0-105037623932);WOS:【SCI-EXPANDED(收录号:WOS:001754577800001)】；

基金：This work was supported by the Natural Science Foundation of Gansu Province (25JRRA809) and General Project of Teaching and Education Research and Reform for Postgraduates of Gansu University of Chinese Medicine (YBXM-202415).

语种：英文

外文关键词：bone regeneration; drug delivery systems; immunomodulation; liposomes; nanomedicine; osteoarthritis; osteomyelitis; osteosarcoma; stimuli-responsive; targeted therapy

摘要：The treatment of complex orthopedic diseases such as osteomyelitis, rheumatoid arthritis, and osteosarcoma is often hindered by the limitations of systemic drug administration, including poor bioavailability, severe side effects, and an inability to address localized pathologies. Liposomes, with their exceptional biocompatibility, structural versatility, and ability to encapsulate diverse therapeutics, have emerged as a cornerstone of nanomedicine. This review provides a function-centric analysis of how liposomes are engineered as intelligent, multi-functional platforms to tackle the specific challenges of the bone microenvironment. We move beyond a simple catalog of applications to critically examine the design strategies that enable liposomes to: (1) penetrate biofilm barriers and eradicate intracellular pathogens in infectious bone diseases; (2) actively target and reprogram inflammatory cells to resolve chronic inflammation in arthritis; (3) provide spatiotemporal control over growth factor and gene delivery for enhanced bone and cartilage regeneration; and (4) enable combinatorial chemo-gene therapies and novel cytotoxic mechanisms for osteosarcoma. By comparing and contrasting these strategies, this review identifies key technological advancements-such as stimuli-responsive release, biomimetic camouflage, and stem-cell fate engineering-that are driving the field forward. We conclude by discussing the persistent challenges for clinical translation and outlining future directions for the next generation of "smart" liposomes that promise to transform the paradigm of orthopedic treatment from symptomatic management to pathology-modifying and regenerative intervention.