文献类型：期刊文献

中文题名：红花化学成分药理作用研究进展及质量标志物预测分析

英文题名：Research Progress on Chemical Constituents and Pharmacological Effects of Carthamus tinctorius and Predictive Analysis on Quality Markers

作者：李响[1];俱蓉[1];李硕[1,2,3,4]

第一作者：李响

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃兰州730000;[3]甘肃省中药质量与标准研究重点实验室培育基地,甘肃兰州730000;[4]西北中藏药协同创新中心,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：23

期号：5

起止页码：928

中文期刊名：中国现代中药

外文期刊名：Modern Chinese Medicine

收录：CSTPCD

基金：国家自然科学基金项目(81960713);甘肃省中医药管理局项目(GZK-2017-7);甘肃省自然科学基金项目(18JR3RA201);甘肃省高校中(藏)药化学与质量研究省级重点实验室项目(zzy-2018-06)。

语种：中文

中文关键词：红花;黄酮类;药理作用;质量标志物

外文关键词：Carthamus tinctorius L.;flavonoids;pharmacological action;Q-marker

摘要：红花为常用活血化瘀药,临床主要用于治疗高血压、冠心病、脑血栓等心脑血管疾病。红花含有黄酮、生物碱、聚炔、亚精胺、甾醇、木脂素、多糖等类化学成分,具有抗心肌缺血、调节血流动力学、抗炎、镇痛、抗氧化、调节免疫力等药理作用。对红花主要化学成分及其药理作用研究进展进行综述,在此基础上,结合质量标志物的研究思路,从化学成分、临床药效、药动学及网络药理学等方面进行红花质量标志物预测分析,为其质量综合评价及临床应用研究提供参考。
Carthamus tinctorius is a commonly used medicine for promoting blood circulation and removing blood stasis.It is mainly used for the clinical treatment of cardiovascular and cerebrovascular diseases such as hypertension,coronary heart disease and cerebral thrombosis.In this paper,the main chemical composition of C.tinctorius such as flavonoids,alkaloids,polyalkynes,spermidines,sterols,lignans,polysaccharides and its pharmacological effects such as anti-myocardial ischemia,regulating hemodynamics,anti-inflammatory,anti-oxidation,regulating immunity were summarized.On this basis,combining with the concept of quality markers,the quality markers of safflower were predicted and analyzed from the aspects of chemical composition,clinical efficacy,pharmacokinetics and network pharmacology,which can establish scientific quality standards of C.tinctorius.