文献类型：期刊文献

英文题名：Causal Relationship Between Air Pollutants and Blood Pressure Phenotypes: A Mendelian Randomization Study

作者：Zhu, Xianshang[1,3];Mao, Huabo[1,3];Zeng, Hongyu[4];Lv, Fengli[4];Wang, Jiancheng[1,2]

第一作者：Zhu, Xianshang

通信作者：Wang, JC[1];Wang, JC[2]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Hlth Vocat Coll, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Hosp, Dept Gen Med, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Hlth Vocat Coll, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：20

期号：1

起止页码：18

外文期刊名：GLOBAL HEART

收录：;Scopus(收录号：2-s2.0-86000221917);WOS:【SCI-EXPANDED(收录号:WOS:001437231700001)】；

基金：This research was funded by grants from the National Natural Science Foundation of China (Grant No. 72264002) , the Key Project of the Traditional Chinese Medicine Education Association (Grant No. 2022KTZ010) , and the Scientific Research Foundation of Gansu Provincial People's Hospital (Grant No. 22GSSYD-55) . The funding organizations and sponsors played no role in the study design, data collection and analysis, manuscript preparation, or decision to publish the findings.

语种：英文

外文关键词：Air pollutants; Blood pressure; Hypertension; Mendelian randomization

摘要：Objectives: Hypertension is a chronic disease widely prevalent around the world. While previous observational studies have suggested a link between air pollutants and an increased risk of hypertension, causality has not been established. Our study aimed to investigate potential causal relationships between five air pollutants and four blood pressure phenotypes through two-sample Mendelian randomization. Methods: Two-sample Mendelian randomization (MR) analyses were performed using genome-wide association studies (GWAS) data from the IEU OpenGWAS project. The main analysis method was the inverse variance weighting (IVW) method. Heterogeneity was assessed by Cochran's Q test, while pleiotropy was assessed by MR-Egger regression. Sensitivity analysis was performed by weighted median method, MR-Egger method, simple mode method, weighted mode method, and leave-one-out analysis method. Results: Mendelian randomization results showed positive causal associations between PM10 with hypertension (OR: 1.49; 95%CI: 1.06, 2.09; P: 2.23 x 10-2) and systolic blood pressure (/3: 1.89; 95%CI: 0.32, 3.47; P: 1.85 x 10-2), positive causal associations between PM2.5 and hypertension (OR: 1.26; 95%CI: 1.01, 2.58; P: 4.30 x 10-2), and negative causal associations between NO2 and systolic blood pressure (/3: -1.71; 95%CI: -3.39, -0.02; P: 4.74 x 10-2). None of the above associations were subject to pleiotropic bias, and all associations were heterogeneous except for PM10 and hypertension. The leave-one-out analysis showed that no single SNP affected the stability of the results. Conclusion: Elevated levels of PM2.5 and PM10 have been associated with an increased risk of developing hypertension, with PM10 specifically linked to higher systolic blood pressure levels. Interestingly, NO2 has shown potential as a protective factor in lowering systolic blood pressure. This study clarifies the causal relationship between five air pollutants and elevated blood pressure. Ensuring good ambient air quality is essential in preventing hypertension and reducing the overall disease burden.