文献类型：期刊文献

英文题名：Labdane-Type Diterpenoids from Leonurus japonicus and Their Plant-Growth Regulatory Activity

作者：Li, Hang-Ying[1];Peng, Xing[1];Jin, Xiaojie[2];Wei, Wen-Jun[1];Ma, Kai-Liang[1];Li, Ya[1];Chen, Jian-Jun[1];Gao, Kun[1]

第一作者：Li, Hang-Ying

通信作者：Chen, JJ[1];Gao, K[1]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：82

期号：9

起止页码：2568

外文期刊名：JOURNAL OF NATURAL PRODUCTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000488424000024)】；

基金：The financial support from the Natural Science Foundation of Gansu Province (18JR4RA003) and the Fundamental Research Funds for the Central Universities (lzujbky-2018-63) is greatly acknowledged.

语种：英文

摘要：Thirteen new labdane-type diterpenoids 1-6, 9-11, 13, 14, 18, and 19 and seven known ones were isolated from the aerial parts of Leonurus japonicus. Compounds 1-5 represent rare examples of labdane-type diterpenoids, of which compounds 1-4 carry an N-chain linked at C-7 in their B-ring and compound 5 featured an alpha,beta-unsaturated-gamma-lactam moiety. The structures and absolute configurations of these new diterpenoids were characterized by a combination of spectroscopic techniques, X-ray crystallography, electronic circular dichroism, and calculated specific rotations. The plant-growth regulatory activity of these compounds on the growth of the roots and shoots of Lactuca sativa and Lolium perenne seedlings were evaluated. Compound 3 showed a broad-spectrum inhibitory activity with the inhibition rates ranging from 60 to 83.5% at a concentration of 200 mu g/mL, which were as active as those of glyphosate. Compound 8 had a selective inhibitory activity against the growth of the roots of L. perenne seedlings with an inhibition rate of 81.7%. However, compounds 11 and 16 exhibited significant stimulation effects on the roots of L. sativa with stimulation rates of 59.8 and 65.3%, respectively. In addition, compounds 3 and 8 exhibited inhibitory effects on the germination of L. perenne seeds.