文献类型：期刊文献

英文题名：Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review

作者：Zhi, Xiaodong[1,2,3,4];Ren, Chunzhen[1,2,3];Li, Qianrong[1,2,3];Xi, Huaqing[1,2,3];Li, Dong[6];Chen, Qilin[1,2,3];Lv, Xinfang[1,2,3,4];Gao, Xiang[1,2,3,4];Wu, Xue[1,2,3,5];Wang, Chunling[1,2,3,4];Jiang, Bing[1,2,3];Mao, Zhongnan[4];Jiang, Hugang[1,2,3];Liu, Kai[1,2,3];Zhao, Xinke[1,2,3,4];Li, Yingdong[1,2,3]

第一作者：支晓东;Zhi, Xiaodong

通信作者：Zhao, XK[1];Li, YD[1];Zhao, XK[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Dingxi Rd, Lanzhou 730000, Peoples R China;[2]Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou 730000, Peoples R China;[3]Natl Adm Tradit Chinese Med, Natl Hlth Commiss Peoples Republ China, Key Specialized Cardiovasc Lab, Key Clin Specialty, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Hosp 2, Lanzhou 730000, Peoples R China;[6]Qingyang Hosp Tradit Chinese Med, Qingyang 745000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Dingxi Rd, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：173

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001206605000001)】；

语种：英文

外文关键词：Angelica sinensis; Organ fibrosis; Hepatic fibrosis; Pulmonary fibrosis; Renal fibrosis; Myocardial fibrosis; Myofibroblast

摘要：Fibrosis -related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern antifibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medicinal value, has garnered attention for its antifibrosis properties in recent investigations. In the past few years, there has been a growing number of experimental inquiries into the impact of angelica polysaccharide (ASP), angelica water extract, angelica injection, and angelica compound preparation on fibrosis -associated ailments, piquing the interest of researchers. This paper aims to consolidate recent advances in the study of Angelica sinensis for the treatment of fibrosis -related disorders, offering insights for prospective investigations. Literature retrieval included core electronic databases, including Baidu Literature, CNKI, Google-Scholar, PubMed, and Web of Science. The applied search utilized specified keywords to extract relevant information on the pharmacological and phytochemical attributes of plants. The investigation revealed that Angelica sinensis has the potential to impede the advancement of fibrotic diseases by modulating inflammation, oxidative stress, immune responses, and metabolism. ASP, Angelica sinensis extract, Angelica sinensis injection, and Angelica sinensis compound preparation were extensively examined and discussed. These constituents demonstrated significant anti -fibrosis activity. In essence, this review seeks to gain a profound understanding of the role of Angelica sinensis in treating fiber -related diseases. Organ fibrosis manifests in nearly all tissues and organs, posing a critical challenge to global public health due to its widespread occurrence, challenging early diagnosis, and unfavorable prognosis. Despite its prevalence, therapeutic options are limited, and their efficacy is constrained. Over the past few years, numerous studies have explored the protective effects of traditional Chinese medicine on organ fibrosis, with Angelica sinensis standing out as a multifunctional natural remedy. This paper provides a review of organ fibrosis pathogenesis and summarizes the recent two decades' progress in treating fibrosis in various organs such as the liver, lung, kidney, and heart. The review highlights the modulation of relevant signaling pathways through multiple targets and channels by the effective components of Angelica sinensis, whether used as a single medicine or in compound prescriptions.