文献类型：期刊文献

英文题名：Expression and Correlation Analysis of PI3K/Akt in Patients with Polycystic Ovary Syndrome (PCOS)

作者：Zhao, Fenqin[1];Xu, Shiqian[1];Yuan, Aiqian[1];Li, Nana[1]

第一作者：赵粉琴

通信作者：Zhao, FQ[1]

机构：[1]Gansu Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2018

卷号：36

期号：6

起止页码：1106

外文期刊名：CHIMICA OGGI-CHEMISTRY TODAY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000456610100330)】；

基金：This study was supported by the Molecular mechanism of Zuogui pill in the treatment of radiation-induced premature ovarian failure based on PI3K/Akt/Foxo3a pathway, project number: 81760806; 2017 National Natural Science Foundation of China.

语种：英文

外文关键词：PCOS (Polycystic ovary syndrome); endometrial hyperplasia; PI3K; AKT

摘要：The role of PI3K/Akt in the pathological expression of patients with Polycystic Ovary Syndrome (PCOS) was investigated with the method of comparative test analysis. First of all, the cases of PCOS patients (52 groups) who had been diagnosed as patients in a department of gynaecology at a 3A hospital were selected as the research objects of the experimental group. In the same period, the non PCOS diagnosis patients (32 groups) were taken as the control group. The experimental group and the control group were not treated with hormonal drugs, and no other types of endocrine history were found. The groups were set as group No.1 (insulin resistance), group No.2 (normal), group A (endometrial carcinogenesis), and group B (normal). The experimental results show that the experimental group and the control group had P>0.05 in the aspect of Akt protein expression, and P<0.05 in the aspect of the P-AKT expression. Group No.1 and group No.2 had P>0.05 of AKT expression. Group A and group B had P>0.05 of AKT expression, and P-AKT results show that group A was superior to group B. There was little correlation among AKT expression and BMI and IR (P>0.05), while P-AKT was positively correlated with the above indexes (P<0.05).