文献类型：期刊文献

中文题名：基于网络药理学探讨半夏厚朴汤作用机制

英文题名：Mechanism Analysis of Banxia Houpu Decoction Based on Network Pharmacology

作者：赵信科[1];孙少伯[2];刘凯[2];蒋虎刚[2];魏惠平[1];付兆媛[1];蔺文燕[2];李应东[2]

第一作者：赵信科

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000;[2]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2020

卷号：35

期号：2

起止页码：379

中文期刊名：中医学报

外文期刊名：Acta Chinese Medicine

收录：CSTPCD

基金：国家重点研发计划资助项目(2018YFC-1705604);2018年中医药防治重大疾病科研课题项目(GZKZD-2018-02)。

语种：中文

中文关键词：半夏厚朴汤;网络药理学;化学成分;生物靶点;信号通路;作用机制

外文关键词：Banxia Houpu Decoction;network pharmacology;chemical composition;biological target;signal pathway;mechanism

摘要：目的:基于网络药理学分析半夏厚朴汤的重要成分与作用机制,为半夏厚朴汤的临床应用、实验研究提供客观依据。方法:基于中药系统药理学分析平台检索半夏厚朴汤的化学成分,以口服生物利用度≥30%和类药性≥0. 18为标准筛选主要活性成分;运用Swiss Target Prediction系统依次检索各活性成分的作用靶点,并构建半夏厚朴汤活性成分-靶点网络图、靶蛋白互作网络图;利用David平台进行KEGG信号通路以及GO生物过程富集分析。结果:通过筛选共挖掘出半夏厚朴汤主要活性成分44个,其相应的作用靶点218个,并筛选出100个关键作用靶点以及10条重要的信号通路。结论:本研究初步揭示了半夏厚朴汤的药效物质基础,并探讨了半夏厚朴汤的药理作用机制,为半夏厚朴汤的临床应用以及实验研究提供了重要参考依据。
Objective: To analyze the important components and mechanism of Banxia Houpu Decoction based on network pharmacology,and to provide objective basis for clinical application and experimental research of Banxia Houpu Decoction. Methods: The chemical constituents of Banxia Houpu Decoction were retrieved based on the TCMSP platform of traditional Chinese medicine system. The main active ingredients were selected based on oral bioavailability (OB) ≥30% and drug-like properties (DL) ≥0. 18. The Swiss Target Prediction was used. The system sequentially searches the active target of each active ingredient,and constructs the active ingredient-target network diagram and target protein interaction network diagram of Banxia Houpu Decoction;the David platform is used for KEGG signal pathway and GO biological process enrichment analysis. Results: A total of 44 main active ingredients of Banxia Houpang Decoction were identified through screening,and 218 targets were correspondingly targeted. 100 key targets and 10 important signal pathways were selected. Conclusion: This study revealed the material basis of Banxia Houpu Decoction,and explored the pharmacological action mechanism of Banxia Houpu Decoction,which provided an important reference for the clinical application and experimental research of Banxia Houpu Decoction.