文献类型：期刊文献

英文题名：The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions

作者：Zheng, Xianli[1,2];Li, Dingpeng[3];Yan, Xingke[1];Yao, Xiaoqiang[2];Wang, Yongrui[1]

第一作者：郑先丽

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Second Peoples Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：18

外文期刊名：FRONTIERS IN NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-85193863811);WOS:【SCI-EXPANDED(收录号:WOS:001228997700001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation Project (No: 81460744), and Gansu Natural Science Foundation Project (No: 21JR1RA266).

语种：英文

外文关键词：5-HTDRN-BNST neural circuit; anxiety; fear; mechanism progress; stress; dysfunction

摘要：Central 5-hydroxytryptaminergic dorsal raphe nucleus (5-HTDRN)-bed nucleus of stria terminalis (BNST) neural circuit dysfunction is one of the important neurobiological basis of anxiety and fear disorders. Under stress, 5-hydroxytryptamine (5-HT) neurons act on BNST receptors to attenuate anxiety and fear responses or enhance anxiety and fear. In BNST, corticotropin releasing factor neurons play a role in regulating emotions by reversely regulating excitatory or inhibitory 5-HT neurons. The composition of 5-HTDRN-BNST neural circuit, the pathological changes of 5-HTDRN-BNST neural circuit function damage under stress, and the effects of 5-HTDRN-BNST neural circuit on anxiety disorder, panic disorder and post-traumatic stress disorder were analyzed and are summarized in this paper. The characteristics of functional changes of the neural circuit and its effects on brain functional activities provide a basis and ideas for the treatment of anxiety and fear disorders through the regulation of 5-HTDRN-BNST neural circuit, and they also provide a new perspective for understanding the pathological mechanism of such diseases.