文献类型：期刊文献

英文题名：JBB attenuates acute and chronic alcoholic liver injury by regulating the NFκB, KEAP1, and HIF1 pathways

作者：Fu, Yuchen[1,2];Zeng, Ziyuan[2];Feng, Siwen[1,2];Chen, Yeyang[3];Ding, Qi[2,4];Shi, Yuanyuan[1,2,4]

第一作者：Fu, Yuchen

通信作者：Ding, Q[1];Shi, YY[1]

机构：[1]Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China;[2]Beijing Univ Chinese Med, Shenzhen Res Inst, Shenzhen, Peoples R China;[3]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Peoples R China;[4]Beijing Univ Chinese Med, Shenzhen Res Inst, 1201, East Block, 16 Lanjingzhong Rd, Shenzhen 518118, Guangdong, Peoples R China

第一机构：Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China

通信机构：[1]corresponding author), Beijing Univ Chinese Med, Shenzhen Res Inst, 1201, East Block, 16 Lanjingzhong Rd, Shenzhen 518118, Guangdong, Peoples R China.

年份：2023

卷号：109

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：;Scopus(收录号：2-s2.0-85171484769);WOS:【SCI-EXPANDED(收录号:WOS:001081552700001)】；

基金：This study was supported by the Basic Research Project of the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20210324135410028) , Science, Technology and Innovation Commission of Shenzhen Municipality (JSGG20220226090203006) , and Nebulized inhalation herbal product development (HSZY0002-01) .

语种：英文

外文关键词：Alcoholic liver injury; Oxidative stress; Inflammatory; Hepatoprotective; Edible herb

摘要：Alcoholic liver disease (ALD) is a liver injury caused by chronic or binge alcohol consumption. Jiubanban (JBB) is a 10-edible-herb-formula. The current study investigated the protective effects and mechanisms of JBB against chronic alcoholic liver injury. The results showed that JBB significantly alleviated chronic alcoholic liver injury caused by chronic-binge alcohol consumption. JBB accelerated ethanol metabolism and had a protective effect on both acute and chronic alcoholic liver injury. By modulating the NF kappa B, KEAP1, and HIF1 pathways, JBB was shown to reduce the production of cytokines (IL-6 and TNF alpha), enhanced the activity of anti-oxidative enzymes (SOD and GSH-px), reduced associated products (ROS and MDA), reversing inflammation, oxidative stress, and apoptosis. The study findings suggest that this functional herbal food combination may be a risk-free therapeutic strategy for treating ALD.