文献类型：期刊文献

英文题名：Effect of flexible sigmoidoscopy-based screening on colorectal cancer incidence and mortality: an updated systematic review and meta-analysis of randomized controlled trials

作者：Zhang, Chengren[1,2,3];Liu, Lili[1,4];Li, Jingjing[1,2,3];Lv, Yaochun[1,2,3];Wu, Dewang[1,2,3];Xu, Shiyun[1,2,3];Cao, Cong[1,2,3];Zhao, Lixia[2,3,4];Liu, Yijun[2,3,4];Ma, Xiaolong[2,3,4];Yang, Xiongfei[1,2,3];Du, Binbin[1,2,3]

第一作者：Zhang, Chengren

通信作者：Yang, XF[1];Du, BB[1]

机构：[1]Gansu Prov Peoples Hosp, Dept Anorectal Surg, Lanzhou, Gansu, Peoples R China;[2]Ningxia Med Univ, Gen Hosp, Yinchuan, Ningxia, Peoples R China;[3]Clin Res Ctr Anorectal Dis Gansu Prov, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Peoples Hosp, Dept Anorectal Surg, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Anorectal Surg, Lanzhou, Gansu, Peoples R China.

年份：2023

卷号：23

期号：11

起止页码：1217

外文期刊名：EXPERT REVIEW OF ANTICANCER THERAPY

收录：;Scopus(收录号：2-s2.0-85167407482);WOS:【SCI-EXPANDED(收录号:WOS:001044235800001)】；

基金：Key Research and Development Program of Science and Technology Department of Gansu Province [22YF7FA097]; Science and Technology Development Program of Lanzhou Science and Technology Bureau [2022-5-51, 2022-5-70, 2022-ZD-47]; Gansu Clinical Medical Research Center for Anorectal Diseases [20JR10RA434]; Scientific Research Fund of Gansu Provincial People's Hospital [21GSSYC-20, 21GSSYC-21, 21GSSYC-23].

语种：英文

外文关键词：Flexible sigmoidoscopy; colorectal cancer; incidence; mortality; meta-analysis; >

摘要：ObjectiveOur objective was to estimate the effect of flexible sigmoidoscopy (FS)-based screening on colorectal cancer (CRC) incidence and mortality by conducting an updated meta-analysis of randomized controlled trials (RCTs).MethodsPubMed, Web of Science, Embase, and Cochrane Library searched for RCTs from database inception to December 2022. The methodological quality of the RCTs was assessed using the Cochrane Collaboration Risk of Bias Tool. RevMan 5.4 was used for this meta-analysis.ResultsFour RCTs involving 457, 871 patients were included. This meta-analysis revealed that FS-based screening was associated with a 20% relative risk reduction in CRC incidence [RR = 0.80; 95% CI (0.75, 0.86); P < 0.00001], and a 24% reduction in CRC mortality [RR = 0.76; 95% CI (0.70, 0.82); P < 0.00001]. In addition, this meta-analysis revealed that FS-based screening reduced the incidence[RR = 0.68; 95% CI (0.60, 0.77); P < 0.00001] and mortality[RR = 0.64; 95% CI (0.49, 0.83); P = 0.0007] of distal CRC, but had no significant effect on proximal colon cancer.ConclusionFS-based screening appeared to be effective in reducing distal CRC incidence and mortality in patients at average risk compared to no intervention, but had no significant effect on proximal colon cancer.