文献类型：期刊文献

英文题名：Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer

作者：Ge, L.[1,2,3];Wang, Y-f.[4];Tian, J-h.[2,3];Mao, L.[5];Zhang, J.[6];Zhang, J-h.[7];Shen, X-p.[8];Yang, K-h.[2,3]

第一作者：Ge, L.

通信作者：Yang, KH[1];Yang, KH[2]

机构：[1]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Lanzhou Univ, Evidence Based Med Ctr, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China;[3]Key Lab Evidence Based Med & Knowledge Translat G, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Sch Basic Med Sci, Lanzhou, Peoples R China;[5]Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China;[6]Gansu Univ Tradit Chinese Med, Sch Nursing, Lanzhou, Peoples R China;[7]Tianjin Univ Tradit Chinese Med, Evidence Based Med Ctr, Tianjin, Peoples R China;[8]Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Key Lab Evidence Based Med & Knowledge Translat G, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China.

年份：2016

卷号：41

期号：4

起止页码：383

外文期刊名：JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

收录：;Scopus(收录号：2-s2.0-84976568621);WOS:【SCI-EXPANDED(收录号:WOS:000379683600002)】；

语种：英文

外文关键词：Chinese herb injections; colorectal cancer; FOLFOX; network meta-analysis

摘要：What is known and ObjectiveResearch has indicated that some Chinese herb injections (CHIs) might be beneficial in combination with chemotherapy, including remedies that might be used as effective chemosensitizers and radiosensitizers, or as palliative therapy. Here, we carried out a network meta-analysis to assess the clinical efficacy and safety of CHIs combined with oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) for advanced colorectal cancer (CRC). MethodsPubMed, EMBASE.com, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), Wanfang Database and Chinese Journal Full-text Database were searched from inception to 31 December 2014, to identify relevant randomized controlled trails (RCTs). The risk of bias in included RCTs was evaluated according to the Cochrane Handbook version 5.1.0. Standard pairwise meta-analysis and Bayesian network meta-analysis were performed to compare the efficacy and safety of different CHIs combined with FOLFOX. Data were analysed using STATA 12.0 and WinBUGS1.4 software. Results and discussionWe identified 63 eligible studies (with 4837 patients in total), involving 9 CHIs. Pairwise meta-analysis showed that compared with FOLFOX alone, combinations with Aidi injection and compound matrine injection could significantly improve the overall response rate and quality of life and reduce the incidence of nausea and vomiting (III-IV), diarrhoea (III-IV), thrombocytopenia (III-IV), leukopenia (III-IV) and peripheral neurotoxicity (III-IV). According to results of indirect comparison, there were no statistically significant differences for most of comparison groups. Aidi+FOLFOX, shenqifuzheng+FOLFOX and compound matrine+FOLFOX had the greatest probability of being the best treatment in clinical efficacy and safety, considering the small sample size. What is new and ConclusionsMost of the included studies were of low quality, and there was a scarcity of eligible trials and numbers of participants. Based on currently limited evidence, aidi, shenqifuzheng and compound matrine were superior to other CHIs in patients receiving FOLFOX chemotherapy for advanced CRC. More studies are required to confirm the efficacy of CHIs in combination with FOLFOX for advanced CRC.