文献类型：期刊文献

英文题名：Effects of acupuncture and nicotine patch on smoking: a multicenter, randomized, controlled, double-blind clinical trial

作者：Dai, Runjing[1,2];Ren, Dong[3];Li, Binning[4];Zhang, Yanfeng[5];Ma, Xiaojing[3];Zhang, Xiangrong[6];Zhang, Hailiang[2];Zhang, Lina[1];Zeng, Chenchen[1];Jiang, Xiaomei[3];Bao, Shisan[2];Fan, Jingchun[2]

第一作者：Dai, Runjing

通信作者：Bao, SS[1];Fan, JC[1];Jiang, XM[2]

机构：[1]Xian Aerosp Gen Hosp, Hosp Infect Control Dept, Xian, Shaanxi, Peoples R China;[2]Gansu Univ Chinese Med, Ctr Evidence Based Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[3]Gansu Gem Flower Hosp, Dept Psychosomat & Sleep Med, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Lib, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Sch Acupuncture & Tuina, Lanzhou, Gansu, Peoples R China;[6]Hlth Ctr Hekou Town, Dept Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：Xian Aerosp Gen Hosp, Hosp Infect Control Dept, Xian, Shaanxi, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Ctr Evidence Based Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Gem Flower Hosp, Dept Psychosomat & Sleep Med, Lanzhou, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2024

卷号：11

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85200038807);WOS:【SCI-EXPANDED(收录号:WOS:001280035400001)】；

基金：We are grateful to Xingke Yan, Mengqi Cao, Jing Jia and Cailian An, The College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine; Bei Xu and Haiying Yao, Gansu Gem Flower Hospital; Yanbin Wu, Xiaokai Xu and Yu Zhang, Health Center of Hekou Town, and all the staffs who assisted in recruiting. We appreciate the contribution from all the participants in the trial.DAS:The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding authors.r The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Gansu Provincial Department of Education university teachers innovation fund project [grant no. 2024A-084], Gansu Provincial Science and Technology plan (Joint research Fund) project [grant no. 23JRRA1528], Natural Science Foundation Project of Gansu Province [grant no. 22JR5RA589] and the Innovation Fund of Postgraduate, Gansu University of Chinese Medicine [grant no. 2021CX67].

语种：英文

外文关键词：acupuncture; nicotine patch; combined treatment; smoking cessation; withdraw syndrome; randomized clinical trial

摘要：Aims To evaluate the effects of acupuncture and/or nicotine patches on smoking cessation.Methods Eighty-eight participants were randomly allocated into four groups: acupuncture combined with nicotine patch (ACNP), acupuncture combined with sham nicotine patch (ACSNP), sham acupuncture combined with nicotine patch (SACNP), and sham acupuncture combined with sham nicotine patch (SACSNP). The primary outcome was self-reported smoking abstinence verified with expiratory Carbon Monoxide (CO) after 8 weeks of treatment. The modified Fagerstrom Test for Nicotine Dependence (FTND) score, Minnesota Nicotine Withdrawal Scale (MNWS), and the Brief Questionnaire of Smoking Urge (QSU-Brief) score were used as secondary indicators. SPSS 26.0 and Prism 9 software were used for statistical analyses.Results Seventy-eight participants completed the study. There were no significant differences in patient characteristics at baseline across the four groups. At the end of treatment, there was a statistically significant difference (chi 2 = 8.492, p = 0.037) in abstaining rates among the four groups. However, there were no significant differences in the reduction in the number of cigarettes smoked daily (p = 0.111), expiratory CO (p = 0.071), FTND score (p = 0.313), and MNWS score (p = 0.088) among the four groups. There was a statistically significant difference in QUS-Brief score changes among the four groups (p = 0.005). There was no statistically significant interaction between acupuncture and nicotine patch.Conclusion Acupuncture combined with nicotine replacement patch therapy was more effective for smoking cessation than acupuncture alone or nicotine replacement patch alone. No adverse reactions were found in the acupuncture treatment process.Clinical trial registration http://www.chictr.org.cn/showproj.aspx?proj=61969, identifier ChiCTR2100042912.