文献类型：期刊文献

英文题名：Uric acid to high-density lipoprotein cholesterol ratio is associated with the prevalence of diabetic kidney disease in euthyroid patients with type 1 diabetes mellitus in China: A multicenter cross-sectional study

作者：Zhao, Hui[1,2];Wang, Yu[1,3,4];Liu, Yanli[5,6,7];Du, Zouxi[8];Tian, Limin[1,9]

第一作者：Zhao, Hui

通信作者：Tian, LM[1];Tian, LM[2]

机构：[1]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Nephrol, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Peoples R China;[4]Clin Res Ctr Metab Dis, Lanzhou, Peoples R China;[5]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China;[6]Lanzhou Univ, Res Ctr Med Device Regulatory Sci, Lanzhou, Peoples R China;[7]Ind Ctr Evidence Based Res & Evaluat Stand Med Dev, Lanzhou, Peoples R China;[8]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[9]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Endocrinol, Chengdu, Peoples R China

第一机构：甘肃中医药大学中西医结合学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Endocrinol, Chengdu, Peoples R China.|[10735ed249c6606940a33]甘肃中医药大学中西医结合学院;[10735]甘肃中医药大学;

年份：2025

外文期刊名：JOURNAL OF DIABETES INVESTIGATION

收录：;Scopus(收录号：2-s2.0-105009344096);WOS:【SCI-EXPANDED(收录号:WOS:001518850300001)】；

基金：We gratefully acknowledge Professor Jie Liu from the Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, for his insightful comments on the manuscript. We acknowledge the valuable data contributions from Dingxi People's Hospital, Zhangye People's Hospital Affiliated to Hexi University, Longnan First People's Hospital, Affiliated Hospital of Gansu Medical College, Baiyin First People's Hospital, Jiayuguan Jiuquan Hospital, Tianshui First People's Hospital, Tianshui Center Hospital, Jinchang People's Hospital, Qingyang People's Hospital, Jiayuguan First People's Hospital, Wuwei People's Hospital, Gannan People's Hospital of Gansu Province, and Qingyang Second People's Hospital. We also thank all study staff and participants for their contributions.

语种：英文

外文关键词：Euthyroid; Type 1 diabetic kidney disease; Uric acid to high-density lipoprotein cholesterol ratio

摘要：Introduction: Globally, the inadequate diagnosis and treatment of diabetic kidney disease remains a significant challenge, impeding effective management. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has been associated with type 2 diabetes; however, its role in euthyroid patients with type 1 diabetic kidney disease (T1DKD) remains unclear. The aim of this study was to assess the association between UHR and T1DKD in patients with euthyroidism. Methods: This cross-sectional study included 335 euthyroid patients with type 1 diabetes mellitus (T1DM) from 1,485 eligible participants. Sociodemographic and blood test data were collected from inpatients of the endocrinology departments of 18 hospitals in Gansu Province. Results: Among the 335 euthyroid patients with T1DM (mean age 35.5 years, 57.6% males), 49.6% had T1DKD. In the fully adjusted model, T1DKD was positively associated with UHR (odds ratio [OR] = 2.29; 95% confidence interval [CI]: 1.36-3.87; P = 0.002). A positive relationship between T1DKD and UHR was also observed (nonlinear, P = 0.575). Subgroup analysis showed that this independent association remained consistent regardless of sex, body mass index, nationality, and marital status. The predictive value of UHR was similar to 22% higher in adults than in individuals aged <18 years. Conclusions: UHR is positively related to DKD in patients with euthyroid T1DM. Assessing the UHR might be a valuable part of follow-up visits for patients with T1DM.