文献类型：期刊文献

中文题名：肝癌相关信号通路的中药调控研究进展

英文题名：Chinese Medicine Regulates Hepatocellular Carcinoma-related Signaling Pathways:A Review

作者：于春[1];高芬[1];郑兰兰[1];郭才[1];何燕芳[1];谢娇娇[1];张轩[1];马燕花[1]

第一作者：于春

机构：[1]甘肃中医药大学第一临床医学院,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：30

期号：15

起止页码：232

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金地区基金项目(81860821);甘肃省科技计划项目(23JRRA1523)。

语种：中文

中文关键词：中药;肝癌;信号通路;研究进展

外文关键词：Chinese medicine;hepatocellular carcinoma;signaling pathway;research progress

摘要：肝癌是一种在消化道中常见的肿瘤,其形成机制尚未完全被揭示。在肝癌的治疗方面,虽然手术、放疗、化疗、靶向治疗及免疫疗法等方式已经取得显著的成果,但这些治疗手段也伴随着相当数量的不良反应和并发症。近年来,中药在肝癌治疗中表现出了显著的疗效,基础实验和临床研究已经证实了中药的功效。中药以其多成分、多靶点的特性来应对疾病,然而肝癌的发病机制异常复杂且尚未完全解析,这也意味着中药在防治肝癌过程中的具体作用机制仍不为人了解。为此,可以运用网络药理学及分子生物学等技术,以更深入地挖掘中药在治疗疾病过程中的作用机制。研究显示,中药可以调控丝裂原活化蛋白激酶(MAPK)信号通路、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路、刺猬(Hedgehog)信号通路、Wnt/β-连接蛋白(β-catenin)信号通路、核转录因子-κB (NF-κB)信号通路、Janus激酶2/信号转导及转录激活因子3(JAK2/STAT3)信号通路及转化生长因子-β (TGF-β)/Smad信号通路等途径,从而通过诱导细胞凋亡、抑制细胞增殖和迁移、阻滞细胞周期等方面展现其抗肝癌效果。然而,对其系统性认知尚不充分。该研究旨在全面研究中药对肝癌相关信号通路的调控作用,以揭示中药在肝癌治疗中的分子作用机制。这一研究有望为肝癌治疗提供新的靶点、新的视角和新的疗法,推动中医药现代化的进程和发展。
Hepatocellular carcinoma(HCC)is a common tumor in the digestive tract,the formation mechanism of which remains to be fully elucidated.Although surgery,radiation,chemotherapy,targeted therapy,and immunotherapy have achieved significant results in the treatment of HCC,these methods are accompanied by a considerable number of adverse reactions and complications.In recent years,Chinese medicine has shown remarkable efficacy in the treatment of HCC,and both basic experiments and clinical studies have confirmed the effectiveness of Chinese medicine,which exerts therapeutic effects via multiple components and multiple targets.However,the pathogenesis of HCC is exceptionally complex and not fully understood,which means that studies remain to be carried out regarding the specific mechanism of Chinese medicine in preventing and treating HCC.Network pharmacology and molecular biology can be employed to decipher the mechanism of Chinese medicine in the treatment of diseases.Studies have shown that Chinese medicine can regulate various pathways such as the mitogen-activated protein kinase(MAPK),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),Hedgehog,Wnt/β-catenin,nuclear factor-κB(NF-κB),Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3),and transforming growth factor-β(TGF-β)/Smad signaling pathways.Chinese medicine can exhibit its anti-HCC effects by inducing cell apoptosis,inhibiting cell proliferation and migration,and blocking the cell cycle via the above pathways.However,the specific mechanisms remain to be systematically studied.This study comprehensively reviews the regulatory effects of Chinese medicine on HCC-related signaling pathways to reveal the molecular mechanisms of Chinese medicine in the treatment of HCC.This view holds the promise of providing new targets,new perspectives,and new therapies for HCC treatment and advancing the modernization and development of Chinese medicine.