文献类型：期刊文献

英文题名：Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities

作者：Zhong, Kexin[1];Du, Xiaojuan[1];Niu, Yuanyuan[1];Li, Zhengju[1];Tao, Yongbiao[1];Wu, Yuqian[1];Zhang, Ruiting[1];Guo, Linjing[1];Bi, Yurong[2];Tang, Lijuan[3];Dou, Tianyu[4];Wang, Longde[5]

第一作者：Zhong, Kexin

通信作者：Wang, LD[1]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Peoples R China;[2]Lanzhou Univ, Sch Life Sci, Key Lab Cell Act & Stress Adaptat, Minist Educ, Lanzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[4]China Jiliang Univ, Coll Life Sci, Hangzhou, Peoples R China;[5]Gansu Univ Chinese Med, Affiliated Hosp, Dept Gastroenterol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Gastroenterol, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：11

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85211577329);WOS:【SCI-EXPANDED(收录号:WOS:001372257800001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by Natural Science Foundation of China, No. 82160883.

语种：英文

外文关键词：duodenal abnormalities; functional dyspepsia; mitochondrial autophagy; pathogenesis; gastrointestinal dysfunction

摘要：Mitochondria are the main source of energy for cellular activity. Their functional damage or deficiency leads to cellular deterioration, which in turn triggers autophagic reactions. Taking mitochondrial autophagy as a starting point, the present review explored the mechanisms of duodenal abnormalities in detail, including mucosal barrier damage, release of inflammatory factors, and disruption of intracellular signal transduction. We summarized the key roles of mitochondrial autophagy in the abnormal development of the duodenum and examined the in-depth physiological and pathological mechanisms involved, providing a comprehensive theoretical basis for understanding the pathogenesis of functional dyspepsia. At present, it has been confirmed that an increase in the eosinophil count and mast cell degranulation in the duodenum can trigger visceral hypersensitive reactions and cause gastrointestinal motility disorders. In the future, it is necessary to continue exploring the molecular mechanisms and signaling pathways of mitochondrial autophagy in duodenal abnormalities. A deeper understanding of mitochondrial autophagy provides important references for developing treatment strategies for functional dyspepsia, thereby improving clinical efficacy and patient quality of life.