文献类型：期刊文献

英文题名：Systematic review and network meta-analysis of non-invasive respiratory support in paediatric patients with acute hypoxaemic respiratory failure: a protocol

作者：Feng, Yan-Dong[1];Li, Yu-Xia[2];Qin, Jin[3];Yin, Yang-Qi[4];Ling, Ji-Zu[1]

第一作者：Feng, Yan-Dong

通信作者：Ling, JZ[1]

机构：[1]Lanzhou Univ, Dept Pediat, Hosp 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Dept Pediat, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Lanzhou Univ Lib, Lanzhou, Gansu, Peoples R China;[4]Tianjin Childrens Hosp, Tianjin, Hebei, Peoples R China

第一机构：Lanzhou Univ, Dept Pediat, Hosp 1, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Dept Pediat, Hosp 1, Lanzhou, Gansu, Peoples R China.

年份：2024

卷号：14

期号：11

起止页码：e088029

外文期刊名：BMJ OPEN

收录：;Scopus(收录号：2-s2.0-85209158629);WOS:【SCI-EXPANDED(收录号:WOS:001353895000001)】；

基金：The Lanzhou University First Hospital's Research Center for Clinical Medicine and the Lanzhou University Evidence-Based Medicine Center provided assistance and guidance in the development of this protocol.

语种：英文

外文关键词：Network Meta-Analysis; Paediatric intensive & critical care; Randomized Controlled Trial

摘要：Introduction Acute hypoxic respiratory failure (AHRF) is one of the most common causes of admission to paediatric intensive care units (PICUs) around the world, posing a serious health concern for the global community. Non-invasive respiratory support (NRS) is considered effective in reducing mortality and intubation rates in adults. However, it is not yet clear whether NRS is beneficial for children and which NRS modalities are most effective. This network meta-analysis aims to summarise existing evidence and compare the efficacy and safety of different NRS modalities in paediatric patients with acute hypoxaemic respiratory failure. Methods and analysis To identify randomised controlled trials, we will perform a systematic search of key databases (Embase, PubMed, CENTRAL, CINAHL Complete and Web of Science) and registered clinical trials (ClinicalTrials.gov, WHO ICTRP and ISRCTN). To ensure the inclusion of the latest literature, an initial pilot search was conducted on 8 July 2024, and an updated search will be conducted after the main research work of this study. AHRF in children treated with NRS will be included. Hospital mortality, intubation rate, treatment failure rate and serious adverse events are critical outcomes closely related to patient-centredness and importance. Two authors will independently select the studies and extract the data. The risk of bias will be assessed using the Cochrane risk of bias tool V.2.0. In order to compare the effects of different NRS modalities, pairwise meta-analysis and network meta-analysis will be conducted using R software. Several subgroup analyses will be conducted, including analyses of different causes of AHRF. We will conduct sensitivity analyses by excluding studies with a high risk of bias and those involving neonates. Using the Grading of Recommendations Assessment, Development and Evaluation methodology, we will assess the certainty of the evidence for the effect estimates of all the outcomes. Ethics and dissemination Since this research is a network meta-analysis based on published literature, no formal ethics approval is required. The results will be disseminated through a peer-reviewed journal for publication. PROSPERO registration number CRD42024529804.