文献类型：期刊文献

中文题名：非抗菌药物抗感染治疗的潜在机制及应用研究进展

英文题名：Potential mechanisms and research progresses in non-antimicrobial drugs in anti-infective therapies

作者：孙滢滢[1];吴耀周[2];王瑞瑞[1];魏莲花[1,3]

第一作者：孙滢滢

机构：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000;[2]兰州大学第一临床医学院,甘肃兰州730000;[3]甘肃省人民医院临床检验中心,甘肃兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2025

卷号：35

期号：11

起止页码：1735

中文期刊名：中华医院感染学杂志

外文期刊名：Chinese Journal of Nosocomiology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(81960385);甘肃省人民医院博士生导师培育基金资助项目(22GSSYA-2)。

语种：中文

中文关键词：药物再利用;非抗菌药物;细菌耐药性;抗菌机制;抗感染治疗

外文关键词：Drug repurposing;Non-antimicrobial drug;Bacterial resistance;Antimicrobial mechanism;Anti-infectiontherapy

摘要：细菌耐药性已成为人类面临的公共卫生威胁之一。当细菌对多种抗菌药物产生耐药性时,感染将难以控制,往往需使用更具毒副作用的药物或更高剂量的抗菌药物,给临床抗感染治疗带来前所未有的挑战。因此,迫切需要开发新的抗菌药物。然而,抗菌药物的研发面临高成本,缺乏新靶点以及市场激励不足等问题,导致新药研发进展缓慢。利用已知药理和毒理学的非抗菌药物进行抗感染治疗已成为研究热点,为抗菌治疗开辟了新途径。本文综述了非甾体抗炎药、抗抑郁药、他汀类药物、降压药、降糖药、抗肿瘤药、抗血小板药、抗组胺药、性激素、局部麻醉药、质子泵抑制剂和驱虫药在抗感染治疗方面的研究进展,总结了抗菌机制。这不仅扩展了人们对这些药物抗感染的认识,还推动了这些药物在临床上的再评价和再利用,为应对细菌耐药问题提供了新思路。
Bacterial drug resistance has become one of the public health threats facing humanity.When bacteria de-velop resistance to multiple antimicrobial agents,infections become difficult to control,often requiring the use of drugs with greater toxicity or higher doses of antimicrobial agents,posing unprecedented challenges to clinical an-ti-infective treatment.Therefore,there is an urgent need to develop new antimicrobial drugs.However,the devel-opment of antimicrobial drugs is confronted with high costs,a lack of new targets,and insufficient market incen-tives,all of which have led to slow progress in new drug development.Anti-infective therapy using non-antimicro-bial drugs with known pharmacology and toxicology has become a research hotspot,opening up new avenues for antimicrobial therapy.This article reviews the latest research progress on the anti-infective effects of nonsteroidal anti-inflammatory drugs,antidepressants,statins,antihypertensive drugs,antidiabetic drugs,antitumor drugs,antiplatelet drugs,antihistamines,sex hormones,local anesthetics,proton pump inhibitors,and anthelmintics,and summarizes their antimicrobial mechanisms.This not only expands our understanding of the anti-infective properties of these drugs but also promotes their re-evaluation and reutilization in clinical practice,providing new strategies for addressing the issue of bacterial resistance.