文献类型：期刊文献

英文题名：

Safety and Efficacy of Tirofiban During Intravenous Thrombolysis Bridging to Mechanical Thrombectomy for Acute Ischemic Stroke Patients: A Meta-Analysis

作者：Li, Wei[1,2,3];Lin, Guohui[4];Xiao, Zaixing[2,3];Zhang, Yichuan[2,3];Li, Bin[2,3];Zhou, Yu[3,5];Chai, Erqing[2,3]

第一作者：Li, Wei;李伟

通信作者：Chai, ER[1];Chai, ER[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Peoples Hosp, Cerebrovasc Dis Ctr, Lanzhou, Peoples R China;[3]Key Lab Cerebrovasc Dis Gansu Prov, Lanzhou, Peoples R China;[4]Gansu Prov Matern & Child Care Hosp, Day Treatment Ctr 2, Lanzhou, Peoples R China;[5]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Cerebrovasc Dis Ctr, Lanzhou, Peoples R China;[2]corresponding author), Key Lab Cerebrovasc Dis Gansu Prov, Lanzhou, Peoples R China.

年份：2022

卷号：13

外文期刊名：FRONTIERS IN NEUROLOGY

收录：;Scopus(收录号：2-s2.0-85130279783);WOS:【SCI-EXPANDED(收录号:WOS:000796276700001)】；

语种：英文

外文关键词：tirofiban; acute ischemic stroke; intravenous thrombolysis; mechanical thrombectomy; meta analysis

摘要：Introduction:& nbsp;The safety and efficacy of tirofiban in intravenous thrombolysis (IVT) bridging to mechanical thrombectomy in patients with acute ischemic stroke (AIS) is unknown. The purpose of this meta-analysis was to evaluate the safety and efficacy of tirofiban in IVT bridging to mechanical thrombectomy in acute ischemic stroke.& nbsp;Methods:& nbsp;We systematically searched PubMed, EMBASE, Web of Science, and The Cochrane Library, CNKI, and Wan Fang databases for randomized controlled trials and observational studies (case-control studies and cohort studies) comparing the tirofiban and non-tirofiban groups in AIS intravenous thrombolysis bridging to mechanical thrombectomy (Published by November 20, 2021). Our primary safety endpoints were symptomatic cerebral hemorrhage (sICH), intracranial hemorrhage (ICH), postoperative re-occlusion, and 3-month mortality; the efficacy endpoints were 3-month favorable functional outcome (MRS <= 2) and successful recanalization rate (modified thrombolytic therapy in cerebral infarction (mTICI) 2b or 3).& nbsp;Results:& nbsp;A total of 7 studies with 1,176 patients were included in this meta-analysis. A comprehensive analysis of the included literature showed that the difference between the tirofiban and non-tirofiban groups in terms of successful recanalization (OR = 1.19, 95% Cl [0.69, 2.03], p = 0.53, I-2 = 22%) and favorable functional outcome at 3 months (OR = 1.13, 95% Cl [0.81, 1.60], p = 0.47, I-2 = 17%) in patients with IVT bridging mechanical thrombectomy of AIS was not statistically significant. Also, the differences in the incidence of sICH (OR = 0.97, 95% Cl [0.58, 1.62], p = 0.89) and ICH (OR = 0.83, 95% Cl [0.55, 1.24], p = 0.36) between the two groups were not statistically significant. However, the use of tirofiban during IVT bridging mechanical thrombectomy reduced the rate of postoperative re-occlusion (OR = 0.36, 95% Cl [0.14, 0.91], p = 0.03) and mortality within 3 months (OR = 0.54, 95% Cl [0.33, 0.87], p = 0.01) in patients.& nbsp;Conclusion:& nbsp;The use of tirofiban during IVT bridging mechanical thrombectomy for AIS does not increase the risk of sICH and ICH in patients and reduces the risk of postoperative re-occlusion and mortality in patients within 3 months. However, this result needs to be further confirmed by additional large-sample, multicenter, prospective randomized controlled trials.Systematic Review Registration, identifier: CRD42022297441.