文献类型：期刊文献

英文题名：A comprehensive analysis of the potential of two closely related species from the genus Codonopsis as supplementary sources for Codonopsis radix based on metabolomics

作者：Liu, Sha[1,2];Chen, Haoran[1,2];Wang, Xiaoshuang[1,2];Li, Shuo[3];Wang, Pan[4];Yang, Guohua[1];Yang, Xingyue[1];Chen, Beibei[1];Xie, Jian[1];Wu, Faming[1];He, Yuqi[1]

第一作者：Liu, Sha

通信作者：Wu, FM[1];He, YQ[1]

机构：[1]Zunyi Med Univ, Guizhou Engn Res Ctr Ind Key Technol Dendrobium No, Guizhou Engn Res Ctr Orchid Med Plant Breeding & E, Zunyi 563000, Guizhou, Peoples R China;[2]Zunyi Med Univ, Guizhou Key Lab Modern Tradit Chinese Med Creat, Zunyi 563000, Guizhou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730101, Peoples R China;[4]Gansu Hlth Vocat Coll, Lanzhou 730207, Peoples R China

第一机构：Zunyi Med Univ, Guizhou Engn Res Ctr Ind Key Technol Dendrobium No, Guizhou Engn Res Ctr Orchid Med Plant Breeding & E, Zunyi 563000, Guizhou, Peoples R China

通信机构：[1]corresponding author), Zunyi Med Univ, Guizhou Engn Res Ctr Ind Key Technol Dendrobium No, Guizhou Engn Res Ctr Orchid Med Plant Breeding & E, Zunyi 563000, Guizhou, Peoples R China.

年份：2026

卷号：26

期号：1

外文期刊名：BMC PLANT BIOLOGY

收录：;Scopus(收录号：2-s2.0-105031450656);WOS:【SCI-EXPANDED(收录号:WOS:001701957100001)】；

基金：This work was supported by National Natural Science Foundation of China (No.32560675, NO.82060687), Guizhou Provincial Science and Technology Projects (Qiankehe foundation MS (No.[2025]379)), Project on Traditional Chinese Medicine and Ethnic Medicine Science and Technology of Guizhou Provincial Administration of Traditional Chinese Medicine (QZYY-2025-020), Zunyi City Science and Technology Plan Project (ZunShiKehe HZ Zi (2024) 316), The 2021 Academic Novice Training and Innovation Exploration Project at Zunyi Medical University (Qianke Platform Talents [2021]1350-051), Guizhou Key Laboratory of Modern Traditional Chinese Medicine Creation (Qian Ke He Platform ZSYS [2025]019), Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile (QKJ [2022]048), and The Department of Science and Technology of Guizhou Province (QKHPTRC-CXTD [2023]024, QKHPTRC-GCC[2023]075).

语种：英文

外文关键词：Codonopsis radix; Supplementary source; Metabolic substance; Codonopsislanceolata; Codonopsistubulosa

摘要：Codonopsis Radix (CR) is a widely used canonical medicinal and edible herb. Its official botanical sources, including C. pilosula (CP), C. pilosula var. modesta (CPM), and C. tangshen (CTS), are geographically constrained. This limited distribution has led to the use of local alternatives, such as C. lanceolata (CL) and C. tubulosa (CT). The scientific basis for substituting these alternatives remains unvalidated. In this study, untargeted metabolomics, network pharmacology, and quantitative analysis were integrated to assess metabolic similarity and identify distinctive bioactive components. Our results demonstrated a conserved core metabolome, with over 90% similarity in metabolite types and 18 shared core active compounds, suggesting a common basis for their traditional medicinal use. Notably, CT exhibited the highest polysaccharide content, and CL was significantly enriched in amino acids. This study not only provides metabolic evidence to support the use of CL and CT as qualified potential supplementary resources for CR but also proposes a dual-track strategy: their core metabolic conservation forms a solid foundation for their potential use as substitutes, while their specialized metabolite enrichment opens avenues for developing targeted functional foods and regionally distinct medicinal products.