文献类型：期刊文献

中文题名：针刺治疗后抑郁症患者脑功能磁共振成像的改变:ALE元分析

英文题名：Brain functional magnetic resonance imaging changes in patients with depression after acupuncture treatment:ALE meta-analysis

作者：汤静[1];余娟[1];耿子尧[1];岳娅婷[1];张静霞[2]

第一作者：汤静

机构：[1]甘肃中医药大学卫生管理学院,兰州730000;[2]甘肃省第二人民医院,西北民族附属医院心理卫生科,兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：34

期号：11

起止页码：1005

中文期刊名：中华行为医学与脑科学杂志

外文期刊名：Chinese Journal of Behavioral Medicine and Brain Science

收录：;北大核心:【北大核心2023】；

基金：甘肃省教育科技创新项目(2025B-124);甘肃中医药大学"岐黄英才"导师专项基金(ZYXKSD-202433);甘肃省卫生健康行业科研计划项目(GSWSKY-034)。

语种：中文

中文关键词：抑郁症;针刺;功能磁共振成像;激活似然估计

外文关键词：Depression;Acupuncture;Functional magnetic resonance imaging;Activation likelihood estimation

摘要：目的采用激活似然估计(ALE)元分析,系统整合针刺治疗抑郁症的功能磁共振成像研究证据,分析针刺对抑郁症患者大脑活动的影响,并系统揭示其潜在的神经机制。方法在中国知网数据库、维普数据库、万方数据库、PubMed、Embase、EBSCOhost-MEDLINE和Web of Science数据库,检索采用功能性磁共振成像研究抑郁症患者在接受针刺干预后脑影像改变的文献。检索时间为从建库至2025年3月。采用ALE法基于Ginger ALE 2.3软件进行数据处理,提取纳入研究的被试的坐标,对抑郁症患者自发脑活动异常的脑区进行整合分析。结果本研究共纳入28篇文献,涉及770个被试。接受针刺治疗的抑郁患者双侧额内回和双侧前扣带回的脑区活动增加(体素和为2744 mm 3,P<0.05)。探索性分析发现,与健康人群相比,接受针刺的抑郁患者相比于健康人群左侧小脑后叶(MNI:x,y,z=-6,-68,-21;x,y,z=-9,-81,-9)激活减弱(体素和为5824 mm 3,P<0.05)。结论接受针刺干预的抑郁患者较未接受针刺干预的抑郁患者、健康人群有较为一致的脑区激活增强,接受针刺干预的抑郁症患者较健康人群左侧小脑后叶激活减弱,提示针刺可能通过调节情绪相关脑区和脑网络的功能状态发挥治疗作用。
Objective Through the meta-analysis of activation likelihood estimation(ALE),the functional magnetic resonance imaging research evidence of acupuncture in the treatment of depression was systematically integrated to analyze the effect of acupuncture on brain activity in patients with depression and systematically reveal its potential neural mechanism.Methods The literatures which used functional magnetic resonance imaging to explore brain image changes of patients with depression after receiving acupuncture intervention were retrieved from CNKI,VIP database,Wanfang database,PubMed,Embase,EBSCO host MEDLINE and Web of Science database.The retrieval time is from the establishment of the database to March 2025.Data processing was performed using the ALE method by the Ginger ALE 2.3 software.The coordinates of the subjects included in the study were extracted,and the brain regions with abnormal spontaneous brain activity in patients with depression were integrated and analyzed.Results A total of 28 articles involving 770 subjects were included.Depressed patients receiving acupuncture exhibited increased brain activity in the bilateral medial frontal gyrus and bilateral anterior cingulate cortex.Exploratory analysis revealed that depressed patients receiving acupuncture exhibited reduced activation in the left posterior cerebellar lobe(MNI:x,y,z=-6,-68,-21;x,y,z=-9,-81,-9)compared to healthy controls(voxel sum=5824 mm 3,P<0.05).ConclusionPatients with depression who received acupuncture intervention exhibited relatively consistent activation in brain regions compared to depressed patients who did not receive acupuncture and healthy individuals.Compared to healthy individuals,patients with depression who received acupuncture showed reduced activation in the left posterior cerebellum.It is suggested that acupuncture intervention may play a therapeutic role by regulating the functional state of emotion-related brain regions and brain networks.