文献类型：期刊文献

中文题名：基于中医传承辅助平台探析清末以前医籍中治疗痛经处方的用药规律

英文题名：Based on the traditional Chinese medicine inheritance auxiliary platform to explore the drug rules of dysmenorrhea prescriptions in medical books before the late Qing

作者：王丽丽[1];沈雪[1];章宪慧[1];王新斌[1]

第一作者：王丽丽

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2022

卷号：42

期号：23

起止页码：2450

中文期刊名：中国医院药学杂志

外文期刊名：Chinese Journal of Hospital Pharmacy

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：甘肃省高等学校创新基金(编号:2021A-077);甘肃省重要管理局科研项目(编号:G2KP-2020-35)。

语种：中文

中文关键词：数据挖掘;中医传承辅助平台;痛经;中医药

外文关键词：data mining;Traditional Chinese Medicine Inheritance Support System(TCMISS)platform;dysmenorrhea;traditional Chinese medicine

摘要：目的:探析清末以前医籍中治疗痛经处方的用药规律。方法:收集清末以前中医古籍中治疗痛经的处方,录入中医传承辅助平台(V2.5),运用无监督聚类分析方法进行分析。结果:纳入中药处方187首,含中药181味,以补虚药、活血化瘀药为主,频次前5味为当归、白芍、川芎、甘草、肉桂;五味以辛、苦、甘为主,药性以温、寒、平居多,主要归肝、脾、心、肾经;分析得出2组不同组合各3种,挖掘出3个潜在新方。结论:痛经以气血亏虚和瘀血为核心病因,不荣、不通为疼痛核心病机,治疗以益气养血、活血化瘀、调经止痛为治疗原则,用药宜攻补兼施,标本同治,重视肝脾心肾的治疗,使气顺、血足、瘀消、寒去,诸症自和,疼痛自止矣,为治疗痛经的临床诊疗及进一步基础研究提供了有益的线索。
OBJECTIVE To explore the prescriptions for dysmenorrhea in the medical books before the late Qing Dynasty.METHODS The prescriptions for dysmenorrhea in ancient Chinese medicine books before the end of the Qing Dynasty were collected and recorded into the Traditional Chinese Medicine Inheritance Support System(TCMISS V2.5) platform, and analyzed by unsupervised clustering analysis method.RESULTS A total of 187 TCM prescriptions were selected, including 181 TCM prescriptions, mainly supplementing deficiency and promoting blood circulation and removing blood stasis. The top 5 ingredients were angelica sinensis, radix paeoniae alba, the rhizome of chuanxiong, licorice and cinnamon. The five tastes mainly were spicy, bitter and sweet, and the medicinal properties were mostly warm, cold and flat, which mainly belonged to the liver, spleen, heart and kidney meridian. Three different combinations were found in each group for two groups, and three potential new prescriptions were excavated.CONCLUSION The core causes of dysmenorrhea are qi and blood deficiency and blood stasis, and the core pathogenesis of dysmenorrhea is inprosperity and obstruction, therefore, the treatment principles are nourishing qi and blood, promoting blood circulation and removing stasis, regulating menstruation and relieving pain. The prescriptions should combine tonification with purgation, treat both the incidental and fundamental aspects, and emphasis on the treatment of liver, spleen, heart and kidney, so as to make qi shun, blood adequate, stasis eliminated and cold dispelled, and then all symptoms are in harmony with each other, resulting in pain elimination, which provide useful clues for the clinical treatment and further basic research of dysmenorrhea.