文献类型：期刊文献

英文题名：The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway

作者：Wei, Xing[1,2];Sun, Kexin[2];Feng, Peng[1];Huang, Shuang[2];Jiang, Bing[3];Cui, Min[2];Chen, Yuanhuan[2];Xue, Fuchun[2];He, Yuezhen[4];Yao, Jingxi[2];Shang, Jing[2];Mei, Hao[2];Ding, Yanqing[5];Tian, Yongyan[6];Guo, Guangyu[2];Yang, Nan[7];Shi, Zhenggang[2]

第一作者：Wei, Xing

通信作者：Feng, P[1];Shi, ZG[2]

机构：[1]Hexi Univ, Med Coll, Zhangye, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Chinese Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[4]Lanzhou Univ, Dept Tradit Chinese Med, Hosp 1, Lanzhou, Gansu, Peoples R China;[5]Hexi Univ, Zhangye Peoples Hosp, Dept Pediat, Zhangye, Gansu, Peoples R China;[6]Hexi Univ, Res Ctr Silk Rd Tradit Chinese Med, Zhangye, Gansu, Peoples R China;[7]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China

第一机构：Hexi Univ, Med Coll, Zhangye, Gansu, Peoples R China

通信机构：[1]corresponding author), Hexi Univ, Med Coll, Zhangye, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Clin Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105018749505);WOS:【SCI-EXPANDED(收录号:WOS:001590675600001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the following funds: The Science and Technology Plan of Gansu Province (No. 22JR11RG221). Research Development Fund of Gansu University of Chinese Medicine (No. 20YF3FA041). Research Project of Gansu Provincial Administration of Traditional Chinese Medicine (No. GZKP-2023-55). Gansu Provincial Department of Education's Innovation Fund Project for College Teachers (No. 2024B098). Doctoral Research Start-up Fund Project of Hexi University (No. KYQD2022015). Hexi University President's Fund for Young Research Projects (No. QN2023001). Regional Project of the National Natural Science Foundation of China (NSFC) (No. 82460953). Young Doctor Foundation of Higher Education in Gansu Province (2023QB-075).

语种：英文

外文关键词：volatile oil from Acorus tatarinowii; Tourette syndrome; neuroinflammation; p38 MAPK/NLRP3/STAT3; a rat model

摘要：Background Acorus tatarinowii Schott holds a prominent position in Traditional Chinese Medicine, with its earliest record found in the ancient Chinese pharmacopeia, the Shennong's Classic of Materia Medica. It has been widely used for various central nervous system diseases. VOA has been shown to reduce neuroinflammation and repair neurons. However, the in vivo mechanisms by which this volatile oil alleviates neuroinflammation caused by Tourette syndrome remain unclear. Purpose This study aims to investigate the effects and molecular mechanisms of VOA intervention in TS, providing scientific evidence for the potential therapeutic role of VOA in TS and paving the way for new treatment strategies. Methods Forty-eight 3-week-old standard deviation rats were divided into a Blank group (n = 8) and a Model group (n = 40). After establishing the Tourette Syndrome animal model, the Model group rats were randomly divided into the Model, Tiapride, VOA, SB203580 and VOA + SB203580 groups. Following model induction, the respective treatments were administered continuously for 4 weeks. At the end of the intervention, Nissl staining was used to observe neuronal structure, and Enzyme-Linked Immunosorbent Assay, immunofluorescence, immunohistochemistry, RT-qPCR and WB were performed to determine the levels of inflammatory factors and protein expression. Results Nissl staining showed that VOA significantly improved neuronal structure compared to the Model group. Compared to the Model group, the Tiapride, VOA, SB203580 and VOA + SB203580 groups had significantly reduced levels of TNF-alpha, IL-6, CD11b, COX-2, caspase-1, p38 MAPK, p-p38 MAPK, STAT3, p-STAT3, NLRP3, and GSDMD (P < 0.01 or P < 0.05) and significantly increased levels of IL-10 and CD163 (P < 0.01 or P < 0.05). Conclusion VOA significantly alleviates neuroinflammation in TS rats by modulating the activity of the p38 MAPK/NLRP3/STAT3 signaling pathway, thereby improving the pathological characteristics of TS. These findings suggest that VOA could be a potential candidate for treating TS and other neuroinflammation-related diseases.