文献类型：期刊文献

英文题名：Molecular and metabolic landscape of adenosine triphosphate-induced cell death in cardiovascular disease

作者：Wang, Wei[1];Wang, Xue-Mei[2];Zhang, Hao-Long[3];Zhao, Rui[4];Wang, Yong[5];Zhang, Hao-Ling[6];Song, Zhi-Jing[4]

第一作者：王薇

通信作者：Song, ZJ[1];Zhang, HL[2]

机构：[1]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Gansu, Peoples R China;[3]Univ Sains Malaysia, Adv Med & Dent Inst, Bertam 13200, Penang, Malaysia;[4]Gansu Univ Chinese Med, Clin Coll Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Dept Pathol Ctr, Lanzhou 730000, Gansu, Peoples R China;[6]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Penang, Malaysia

第一机构：甘肃中医药大学针灸推拿学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Penang, Malaysia.|[10735]甘肃中医药大学;

年份：2024

卷号：16

期号：12

起止页码：689

外文期刊名：WORLD JOURNAL OF CARDIOLOGY

收录：Scopus(收录号：2-s2.0-85210745545);WOS:【ESCI(收录号:WOS:001413489500006)】；

基金：Supported by National Natural Science Foundation of China, No. 81960877; University Innovation Fund of Gansu Province, No. 2021A- 076; Gansu Province Science and Technology Plan, No. 21JR7RA561; Natural Science Foundation of Gansu Province, No. 21JR1RA267 and No. 24JRRA1020; Education Technology Innovation Project of Gansu Province, No. 2022A-067; Open Project of Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education, No. DHYX21-07, No. DHYX22-05, and No. DHYX21-01; and Gansu Province Joint Research Fund Project, No. 24JRRA878.

语种：英文

外文关键词：Adenosine triphosphate induced cell death; Cardiovascular diseases; Myocardial ischemia-reperfusion injury; Molecular mechanisms; Metabolic pathways

摘要：The maintenance of intracellular and extracellular adenosine triphosphate (ATP) levels plays a pivotal role in cardiac function. In recent years, burgeoning attention has been directed towards ATP-induced cell death (AICD), revealing it as a distinct cellular demise pathway triggered by heightened extracellular ATP concentrations, distinguishing it from other forms of cell death such as apoptosis and necrosis. AICD is increasingly acknowledged as a critical mechanism mediating the pathogenesis and progression of various cardiovascular maladies, encompassing myocardial ischemia-reperfusion injury, sepsis-induced cardiomyopathy, hypertrophic cardiomyopathy, arrhythmia, and diabetic cardiomyopathy. Consequently, a comprehensive understanding of the molecular and metabolic underpinnings of AICD in cardiac tissue holds promise for the prevention and amelioration of cardiovascular diseases. This review first elucidates the vital physiological roles of ATP in the cardiovascular system, subsequently delving into the intricate molecular mechanisms and metabolic signatures governing AICD. Furthermore, it addresses the potential therapeutic targets implicated in mitigating AICD for treating cardiovascular diseases, while also delineating the current constraints and future avenues for these innovative therapeutic targets, thereby furnishing novel insights and strategies for the prevention and management of cardiovascular disorders.