文献类型：期刊文献

英文题名：Prophylactic use of vitamin k in special neonatal populations: a quality assessment of clinical guidelines

作者：Liu, Yanli[1,2,3];Zhao, Yue[4];Wang, Zhe[1,2,3];Ding, Fengxing[1,2,3];Yi, Shaowei[1,2,3];Luo, Yating[1,2,3];Du, Wanxian[1,2,3];Xue, Jing[1,2,3];Ruan, Jianhua[1,2,3];Zhou, Xiyao[1,2,3];Zhu, Jingwen[6];Gao, Xiaoni[6];Xie, Guangmei[5];Guo, Ming[6];Ma, Bin[1,2,3,7]

第一作者：Liu, Yanli

通信作者：Ma, B[1];Ma, B[2];Ma, B[3];Xie, GM[4];Guo, M[5];Ma, B[6]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Res Ctr Med Device Regulatory Sci, Lanzhou 730000, Peoples R China;[3]Ind Ctr Evidence Based Res & Evaluat Stand Med Dev, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[5]Gansu Maternal & Child Hlth Care Hosp, Gansu Prov Cent Hosp, Reprod Med Ctr, 999 Mogao Ave, Lanzhou 730050, Gansu, Peoples R China;[6]FengTai Maternal & Child Hlth Hosp, Beijing 100067, Peoples R China;[7]Key Lab Evidence Based Med Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[2]corresponding author), Lanzhou Univ, Res Ctr Med Device Regulatory Sci, Lanzhou 730000, Peoples R China;[3]corresponding author), Ind Ctr Evidence Based Res & Evaluat Stand Med Dev, Lanzhou 730000, Gansu, Peoples R China;[4]corresponding author), Gansu Maternal & Child Hlth Care Hosp, Gansu Prov Cent Hosp, Reprod Med Ctr, 999 Mogao Ave, Lanzhou 730050, Gansu, Peoples R China;[5]corresponding author), FengTai Maternal & Child Hlth Hosp, Beijing 100067, Peoples R China;[6]corresponding author), Key Lab Evidence Based Med Gansu Prov, Lanzhou 730000, Peoples R China.

年份：2025

卷号：184

期号：12

外文期刊名：EUROPEAN JOURNAL OF PEDIATRICS

收录：;Scopus(收录号：2-s2.0-105023218106);WOS:【SCI-EXPANDED(收录号:WOS:001627986400005)】；

语种：英文

外文关键词：Vitamin K prophylaxis; Special neonatal populations; Clinical practice guidelines; Quality assessment

摘要：Vitamin K deficiency bleeding (VKDB) is a serious neonatal condition. Despite widespread prophylaxis, a unified and explicit prevention strategy remains lacking for special neonatal populations. This study systematically searched the PubMed and CNKI databases, along with the websites of relevant guideline-issuing organizations. Clinical practice guidelines published up to June 30, 2025, were included, excluding outdated versions superseded by updated guidelines and documents not published in English or Chinese. Methodological quality was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool, while reporting quality was evaluated using the Reporting Items for Practice Guidelines in Healthcare (RIGHT) checklist. Key data on dosage frequency, amount, route, and timing were extracted. A total of 14 eligible guidelines were included, covering Asia, Europe, the Americas, Oceania, and international organizations, published between 2000 to 2025. The overall methodological and reporting quality of the included guidelines was relatively low. Considerable variability was observed in the recommendations for vitamin K prophylaxis among special neonatal populations, such as preterm infants, low birth weight infants, those with maternal medication exposure, hepatobiliary disease, gastrointestinal malabsorption, birth trauma, surgical needs, or exclusive breastfeeding. These differences were reflected in the route of administration, dosage, timing, and frequency. Most guidelines recommended intramuscular injection with weight-based dosing, while a few provided oral regimens as an alternative.Conclusions: Clinical practice guidelines for vitamin K prophylaxis in special neonatal populations show poor quality and inconsistency. There is a need for high-quality research to clarify individualized supplementation strategies. What is Known:center dot Vitamin K deficiency bleeding (VKDB) is a serious but preventable neonatal hemorrhagic disorder. Prophylactic vitamin K administration has been widely adopted, significantly reducing VKDB incidence.What is New:center dot Certain special neonatal populations-such as those born prematurely, with low birth weight, exposed to interfering maternal medications, or with gastrointestinal/hepatobiliary disorders, etc.-are at high risk for VKDB. Current recommendations vary markedly in dosage, route, and timing, and lack consistent methodological rigor. There is an urgent need for individualized, evidence-based strategies tailored to these vulnerable populations.