文献类型：期刊文献

中文题名：党参超微粉与细粉在大鼠体内的药动学比较研究

英文题名：Comparative pharmacokinetics of ultramicro-powder and fine powder of Radix Codonopsis in rats

作者：窦霞[1,2];靳子明[1,2];甄小龙[1]

第一作者：窦霞

机构：[1]甘肃中医药大学附属医院;[2]甘肃省中药炮制及质控工程技术研究中心

第一机构：甘肃中医药大学第二附属医院

年份：2016

卷号：36

期号：20

起止页码：1749

中文期刊名：中国医院药学杂志

外文期刊名：Chinese Journal of Hospital Pharmacy

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：甘肃省自然科学基金项目(编号:145RJZA155)

语种：中文

中文关键词：党参;超微粉;细粉;药动学

外文关键词：Radix Codonopsis; ultramicro-powder; fine powder; pharmacokinetics

摘要：目的:对党参超微粉与细粉中的有效成分党参炔苷在大鼠体内的药动学进行比较。方法:采用高效液相质谱(HPLC)法分别测定灌服两种样品的大鼠体内党参炔苷的血药浓度,通过DAS 2.0药动学软件处理数据,比较党参超微粉及其细粉在大鼠体内的药动学参数和相对生物利用度。结果:党参炔苷在大鼠体内的血药浓度-时间数据符合单室模型;Cmax分别为1.408,1.932μg·mL^(-1);tmax分别为1,1.5 h;t1/2分别为0.243,0.674 h;V分别为34.701,50.745 L;CL分别为5.281,3.779 L·h^(-1)。党参超微粉相对于细粉,其生物利用度提高了39.7%。结论:党参经超微粉碎后可促进其党参炔苷在大鼠体内的吸收,提高生物利用度。
OBJECTIVE To compare pharmacokinetics of lobetyolin in ultramicro-powder and fine powder of Radix Codonopsis in rats.METHODS Plasma concentration of lobetyolin was determined by HPLC method after Radix Codonopsis were gavaged to rats.Pharmacokinetic parameters were analyzed using a DAS 2.0pharmacokinetic software package.The difference was then compared between ultramicro-powder and fine power of Radix Codonopsis and relative bioavailability was calculated.RESULTS Plasma concentration-time data of lobetyolin were both fitted to single compartment model.Cmaxvalues were separately 1.408μg·mL^-1 and 1.932μg·mL^-1;tmax1 h and 1.5 h;t1/20.243 h and 0.674 h;V 34.701 L and 50.745 L;and CL5.281 L·h^-1 and 3.779 L·h^-1.The relative bioavailability of lobetyolin in ultramicro-powder to fine podwer was increased by39.7%.CONCLUSION Ultramicro-powder can promote absorption of active ingredients compared to fine powder of Radix Codonopsis,and improve bioavailability of lobetyolin in rats.