文献类型：期刊文献

英文题名：Jianpi Huatan Tongfu granule alleviates inflammation and improves intestinal flora in patients with acute exacerbation of chronic obstructive pulmonary disease

作者：Yong, Wenxing[1];Zhang, Liying[2,4];Chen, Yuexuan[1,3];Li, Juan[1];Liu, Yongqi[2,4];Zhang, Zhiming[1]

第一作者：雍文兴

通信作者：Zhang, ZM[1]

机构：[1]Gansu Univ Chinese Med, Dept Emergency, Affiliated Hosp, 732 Jiayuguan West Rd, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[3]Hangzhou Hosp Tradit Chinese Med, Dept Emergency, Hangzhou, Peoples R China;[4]Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Minist Level, Lanzhou, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Dept Emergency, Affiliated Hosp, 732 Jiayuguan West Rd, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2020

卷号：48

期号：4

外文期刊名：JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-85083478542);WOS:【SCI-EXPANDED(收录号:WOS:000529284500001)】；

基金：This study was supported by the National Natural Science Foundation of China (Grant Nos. 81660730 and 81473457), the Open Fund of Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment for Major Diseases for Colleges and Universities in Gansu Province (Grant Nos. FZYX14-2 and FZYX14-7), and the Major Science and Technology Project of Gansu Province (Grant No. 18YF1FA044).

语种：英文

外文关键词：Jianpi Huatan Tongfu granule; acute exacerbation of chronic obstructive pulmonary disease; inflammation; intestinal flora; 16S rDNA; cytokines; C-reactive protein; lung function; dyspnea

摘要：Objectives To investigate the clinical efficacy and mechanism of Jianpi Huatan Tongfu granule in treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty patients with AECOPD were enrolled in either of two groups: integrative treatment (Western medicine combined with Jianpi Huatan Tongfu granule) (n = 30) and Western medical treatment (n = 30). Thirty healthy individuals were included in the control group. Results Compared with healthy participants, patients with AECOPD had elevated clinical symptom and dyspnea severity scores. Patients with AECOPD had worsened lung function, compared with healthy participants. The therapeutic efficacy for integrative treatment was superior to Western medical treatment. Inflammatory proteins and cytokines were significantly elevated in patients with AECOPD, including C-reactive protein, interleukin-6, interleukin-8, and tumor necrosis factor-alpha; these were alleviated by both treatments, with more obvious effects for integrative treatment. Integrative treatment significantly changed the intestinal flora in patients with AECOPD, reaching levels comparable with those of healthy participants. Firmicutes abundance was significantly higher in healthy participants, whereas Bacteroidetes abundance was significantly higher in patients with AECOPD. After treatment, Verrucomicrobia abundance was significantly reduced in patients with AECOPD. Conclusion Jianpi Huatan Tongfu granule could alleviate inflammatory responses and improve clinical therapeutic efficacy in patients with AECOPD.