文献类型：期刊文献

中文题名：基于主成分分析模型的白术药材多指标产地质量评价研究

英文题名：Study on Multi-index Quality Evaluation of Atracylodis Macrocephalae Rhizoma Based on PCA Model

作者：李芳[1];吴红彦[1];吴国泰[1];李钦[1]

第一作者：李芳

机构：[1]甘肃中医药大学

第一机构：甘肃中医药大学

年份：2016

卷号：23

期号：11

起止页码：81

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2015_2016】；

基金：国家自然科学基金(81060284);甘肃省中药药理与毒理学重点实验室开放基金项目(ZDSYS-KJ-2015-005)

语种：中文

中文关键词：白术;白术内酯Ⅰ;白术内酯Ⅲ;白术多糖;主成分分析;质量评价

外文关键词：Atracylodis Macrocephalae Rhizoma; atractylenolide Ⅰ; atractylenolide Ⅲ; atractylodes macrocephalaon polysaccharide; principal component analysis; quality evaluation

摘要：目的建立基于主成分分析(PCA)模型的白术药材多指标产地质量评价方法。方法采用HPLC同时测定白术药材中白术内酯Ⅰ及白术内酯Ⅲ含量,采用苯酚-硫酸法测定白术多糖含量,以2015年版《中华人民共和国药典》通则2201项下热浸法测定醇浸出物含量,采用PCA建立白术药材多指标产地质量评价模型。结果白术内酯Ⅰ及白术内酯Ⅲ在质量浓度范围内呈良好线性关系(r=0.999 9),平均回收率分别为100.9%、102.1%。PCA分析显示,浙江磐安、於潜、缙云及新昌等地所产白术药材质量最佳,安徽亳州及阜阳所产白术药材质量亦佳。结论基于PCA模型的多指标产地质量评价方法能够客观评价不同产地白术药材质量。
Objective To establish a multi-index quality evaluation method of Atracylodis Macrocephalae Rhizoma based on principal component analysis（PCA） model. Methods The contents of atractylenolide Ⅰ and atractylenolide Ⅲ were determined by HPLC; atractylodes macrocephalaon polysaccharide was determined by phenol-sulfuric acid method; ethanol soluble extractum was determined by hot soak in general rule of Chinese Pharmacopoeia（2015 Edition）; PCA was used to establish a multi-index quality evaluation model. Results Atractylenolide Ⅰ and atractylenolide Ⅲ showed good linear correlations（r=0.999 9）, and the average recoveries were 100.9% and 102.1%, respectively. PCA showed that the Atracylodis Macrocephalae Rhizoma from Panan County, Yuqian Town, Jinyun County, Xinchang County of Zhejiang Province had the best quality, from Bozhou City and Fuyang City of Anhui Province had good quality. Conclusion The established multi-index quality evaluation method based on PCA model can be applied to objectively evaluate the quality of Atracylodis Macrocephalae Rhizoma from different producing areas.