文献类型：期刊文献

中文题名：铁超载在骨关节炎发生发展中的作用机制研究进展

英文题名：Research progress on the mechanism of iron overload in the occurrence and development of osteoarthritis

作者：王亮[1];张虎林[2];汪小敏[2];杨超强[1];王宜灿[1];赖学倩[3]

第一作者：王亮

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学附属医院北院骨科,甘肃兰州730000;[3]甘肃中医药大学中西医结合学院,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2022

卷号：27

期号：9

起止页码：1075

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD_E2021_2022】；

基金：甘肃省自然科学基金资助项目(18JR3RA077);兰州市卫生健康科技发展项目(2019-050);兰州市人才创新创业项目(2020-RC-67);甘肃中药大学附属医院青年项目(gzfy-2019-18)。

语种：中文

中文关键词：骨关节炎;铁超载;机制

外文关键词：osteoarthritis;iron overload;mechanism

摘要：骨关节炎(osteoarthritis,OA)是一种常见的慢性退行性疾病,其病情随年龄增长呈不断加重趋势。OA发病机制复杂,许多危险因素均可导致OA的发生。铁作为机体必不可少的微量元素之一,其代谢平衡对人体的健康极其重要。铁超载与OA的发生发展密切相关,关节组织中过多的铁沉积易导致关节软骨和滑膜发生病变以及影响软骨下骨重建导致OA的发生。笔者查阅近几年相关研究文献,就铁超载在OA发生发展过程中的作用机制展开综述,以期为OA发病研究及诊治策略提供新的思路和方向。
Osteoarthritis(OA)is a common chronic degenerative disease,and its condition tends to worsen with age.The pathogenesis of OA is complex,and many risk factors can lead to the occurrence of OA.Iron is one of the essential trace elements in the body,and its metabolic balance is extremely important to human health.Iron overload is closely related to the occurrence and development of OA.Excessive iron deposition in joint tissue can easily lead to lesions of articular cartilage and synovium,as well as affect subchondral bone reconstruction and lead to the occurrence of OA.The author reviewed the relevant research literature in recent years,and reviewed the mechanism of iron overload in the occurrence and development of OA,in order to provide new ideas and directions for the research and diagnosis and treatment of OA.