文献类型：期刊文献

中文题名：Study on the effect of Rhizoma Anemarrhenae on glucose and lipid metabolism in diabetic mice

作者：Jin-Bao Zhang[1,2];Peng-Wei Zhuang[3];Qian Wang[1,2];Chun-Yu He[1,2];Yan-Jun Zhang[3]

第一作者：Jin-Bao Zhang

机构：[1]Gansu University of Chinese Medicine,Lanzhou 730101,China;[2]Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine in Gansu Province,Lanzhou 730101,China;[3]Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China

第一机构：甘肃中医药大学

年份：2021

卷号：1

期号：1

起止页码：28

中文期刊名：TMR药理学研究

外文期刊名：TMR Phatmacology Research

基金：This study was supported by the Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine in Gansu Province(ZDSYS-KJ-2018-007);the 2020 Gansu Provincial Higher Schools Industry Support and Guidance Project(2020C-9);Gansu University of Chinese Medicine Introduced Talent Research Startup Fund Project(2016YJRC-03,2016YJRC-06).

语种：英文

中文关键词：Rhizoma Anemarrhenae;Diabetic mice;Blood glucose;Blood lipids

摘要：Objective:To investigate the effect of Rhizoma Anemarrhenae extract on glucose and lipid metabolism in diabetic mice,and provide basis for follow-up research.Methods:The method of streptozotocin combined with high-fat diet was used to replicate the diabetes model in this study.After continuous intragastric administration for 6 weeks,the effects of Rhizoma Anemarrhenae extract on body weight,blood sugar,blood lipids,serum insulin and the organ index in diabetic mice were detected.Results:The fasting blood glucose and blood lipids(serum total cholesterol,triglyceride,low density lipoprotein cholesterol levels)of the Rhizoma Anemarrhenae group of mice were significantly decreased,which was statistically significant compared with the model group.The area under the curve of the Rhizoma Anemarrhenae group is significantly smaller than that of the model group,and the result is statistically significant.Rhizoma Anemarrhenae can increase serum insulin levels in diabetic mice,which is statistically significant compared with the model group.Compared with the model group,the liver,spleen,kidney and pancreas indexes of the Rhizoma Anemarrhenae group are significantly reduced.Conclusion:The extract of Rhizoma Anemarrhenae can significantly reduce blood glucose concentration,lower blood lipid levels,promote serum insulin secretion,and protect liver,kidney,spleen,pancreas and other tissues and organs.