文献类型：期刊文献

英文题名：Role of Sonazoid-based contrast-enhanced ultrasonography in the microwave ablation of primary hyperparathyroidism

作者：Zhou, Zu-Bang[1];Xue, Ya-E[2];Yao, Yan-Wu[2];Zhang, Xue-Ting[2];Zhang, Ming-Hua[2];Yang, Da-Xiong[2];Xie, Jin-Hui[1]

第一作者：Zhou, Zu-Bang

通信作者：Xie, JH[1]

机构：[1]Gansu Prov Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China.

年份：2022

卷号：39

期号：1

起止页码：155

外文期刊名：INTERNATIONAL JOURNAL OF HYPERTHERMIA

收录：;Scopus(收录号：2-s2.0-85122836238);WOS:【SCI-EXPANDED(收录号:WOS:000740849600001)】；

基金：This work was supported by the Lanzhou Talent Innovation and entrepreneurship Project [2019RC119].

语种：英文

外文关键词：Primary hyperparathyroidism; intact parathyroid hormone; microwave ablation; Sonazoid; contrast-enhanced ultrasound; radiology

摘要：Objectives This study aimed to determine the performance of Sonazoid-based contrast-enhanced ultrasound (CEUS) in the microwave ablation (MWA) of primary hyperparathyroidism (pHPT). Methods Forty patients with pHPT were enrolled and treated with percutaneous ultrasound (US)-guided MWA assisted by CEUS. All patients underwent immediate CEUS examinations following MWA. On post-ablation day 1, patients who did not display a decrease in intact parathyroid hormone (iPTH) levels to the norm were examined by CEUS to evaluate an incomplete ablation. We compared the serum iPTH and calcium levels and the nodule volumes before and after MWA. The complications were evaluated during and after treatment. Results Immediately following MWA, CEUS demonstrated complete ablation with all 44 parathyroid nodules. On post-ablation day 1, five nodules in five patients displayed annular enhancement around the ablation zone on CEUS. The average maximum diameters of the nodules and the ablation zone were 1.09 +/- 0.28 cm and 1.36 +/- 0.23 cm, respectively. An ablation zone larger than the primary lesion (p < 0.05) generated a higher rate of complete ablation. Compared with pre-MWA, serum iPTH and calcium levels were significantly improved. Treatment success was achieved in 38 patients (95%). Hoarseness was a major complication in six patients (15%); however, it improved spontaneously within 1-4 months. We observed two recurrences (2/40, 5%) at 9 months and 11 months following MWA, respectively. Conclusion US-guided percutaneous MWA assisted by CEUS for pHPT is an effective and safe therapy. CEUS can avoid operative failure and improve the cure rate.