文献类型：期刊文献

中文题名：基于全球视域的中医药调控Notch通路文献计量学及可视化分析

英文题名：Bibliometrics and Visualization of the Regulation of Notch Signaling Pathway by TCM Based on Global Perspective

作者：尚辉[1];冉立成[1];陈融[1];宋亚文[2];王亚军[1];陈丽荣[1];杨通[1];郭明亮[1];何慧[1]

第一作者：尚辉

机构：[1]甘肃中医药大学针灸推拿学院,兰州730000;[2]甘肃中医药大学附属医院,兰州730000

第一机构：甘肃中医药大学针灸推拿学院

年份：2025

卷号：27

期号：4

起止页码：1072

中文期刊名：世界科学技术-中医药现代化

外文期刊名：Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金地区项目(82160936):基于Wnt、Notch信号通路的串话探讨针刺对抑郁模型大鼠海马神经干细胞再生的作用机制,负责人:王亚军;甘肃中医药大学“岐黄英才”导师专项基金项目(3016190125):艾灸“足三里”穴对骨髓抑制小鼠骨髓细胞中Wnt5a、Frizzled2、β-catenin分子影响的实验研究,负责人:王亚军;甘肃省针灸临床医学研究中心开放基金项目(ZJKF2212):郑氏家传“舒肝理气方”治疗轻中度抑郁症(肝郁气滞型)的临床研究,负责人:宋亚文。

语种：中文

中文关键词：中医药;Notch信号通路;文献计量学;可视化分析;Citespace;Vosviewer

外文关键词：Chinese medicine;Notch signaling pathway;bibliometrics;Visualization;Citespace;Vosviewer

摘要：目的 基于文献计量学分析国内外中医药调控Notch信号通路防治疾病的研究概况、热点方向与前沿趋势。方法 基于Citespace与Vosviewer文献计量软件对中国知网数据库(CNKI)及科学核心集数据库(WoSCC)中关于中医药调控notch信号通路的中、英文文献进行可视化分析。结果 截至2024年1月,共发表中、英文各362篇与85篇相关文献,从2013年开始该领域文献发表数量呈波动性递增趋势;中国是发文最多的国家;湖南中医药大学为中文数据库发文最多的机构,北京中医药大学为英文文献库发文最多的机构;结合各研究团队的研究方向及关键词聚类、突现分析梳理出中医药调控Notch信号通路的研究热点聚焦在脑缺血、骨髓抑制以及肝纤维化等疾病中。哮喘、结直肠癌等疾病成为近几年新兴的研究方向,中医药疗法抑制卵巢癌细胞增殖、缓解恶性肿瘤化疗后的毒副反应是该领域前沿研究趋势之一。结论 近年来中医药靶向Notch信号通路防治疾病发展迅速,各研究团队获得丰富的研究成果,研究热点呈现多样化趋势,对此深入探索可为中医药治疗多种疾病的分子机制提供有力证据。
Objective To analyze the research status,hot directions and frontier trends of traditional Chinese medicine in the prevention and treatment of diseases by regulating Notch signaling pathway based on bibliometrics.Methods Based on Citespace and Vosviewer,the literature on the regulation of Notch signaling pathway by traditional Chinese medicine in CNKI and WoSCC was visually analyzed.Results 362 and 85 related literatures were published in Chinese and English respectively until January 2024.Since 2013,the number of literatures published in this field has shown a fluctuating increasing trend.China is the country with the most publications;Hunan University of Chinese Medicine were the institutions with the most publications in the Chinese database,and Beijing University of Chinese Medicine was the institution with the most publications in the English literature database.Combined with the research direction of each research team and keyword clustering and burst analysis,the research hotspots of traditional Chinese medicine regulating Notch signaling pathway are focused on cerebral ischemia,myelosuppression and hepatic fibrosis.Diseases such as Asthma,colorectal cancer have become emerging research directions in recent years.Electroacupuncture therapy to promote stem cell proliferation and treat neurological diseases is one of the frontier research trends in this field.Conclusion Recent years have seen a rapid development of traditional Chinese medicine's disease prevention and treatment that targets Notch signaling pathway.Various expert teams have obtained rich research results,and the research hotspots show a diversified trend.In-depth exploration of this can provide strong evidence for the molecular mechanism of traditional Chinese medicine in the treatment of various diseases.