文献类型：期刊文献

中文题名：乳酸/乳酸化修饰对肿瘤相关巨噬细胞的调控作用及其在肿瘤治疗中的研究进展

英文题名：Regulatory effects of lactate/lactylation modification on tumor-associated macrophages and its research progress in tumor therapy

作者：雷鹏飞(综述)[1];王昌荣(综述)[1];刘芳(审校)[1];陈彻(审校)[1]

第一作者：雷鹏飞

机构：[1]甘肃中医药大学公共卫生学院甘肃省中医药研究中心,甘肃兰州730000

第一机构：甘肃中医药大学公共卫生学院

年份：2026

卷号：39

期号：2

起止页码：229

中文期刊名：中国生物制品学杂志

外文期刊名：Chinese Journal of Biologicals

基金：甘肃省中医药管理局项目(GZKZ-2024-37);甘肃省科技计划(22JR11RA124);甘肃省中医药研究中心开放课题(zyzx-2023-06);兰州市科技计划(2023-2-12);甘肃中医药大学科学研究与创新基金(2022KCYB-2)。

语种：中文

中文关键词：乳酸;乳酸化修饰;肿瘤相关巨噬细胞;肿瘤微环境

外文关键词：Lactate;Lactylation;Tumor-associated macrophage(TAM);Tumor microenvironment(TME)

摘要：乳酸是糖酵解途径的关键代谢产物,在肿瘤细胞中通过介导代谢重编程、信号转导及表观遗传修饰直接增强肿瘤细胞的存活、增殖与迁移能力。乳酸化是一种由乳酸诱导的蛋白质翻译后修饰过程,能调控细胞信号、基因表达和蛋白功能,进而影响肿瘤进程。乳酸水平升高是乳酸化形成的关键驱动因素。肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)在肿瘤微环境(tumor microenvironment,TME)中促进肿瘤生长、转移及免疫逃逸,且乳酸可通过乳酸化修饰机制推动TAM极化,促进血管生成并抑制免疫反应,为肿瘤提供有利生存环境。本文就乳酸/乳酸化修饰对TAM功能的调控作用及其在肿瘤治疗中的研究进展作一综述,以期为肿瘤的研究及治疗提供参考。
Lactate,as a key metabolic product of glycolysis,directly enhances the survival,proliferation,and migration of tumor cells by mediating metabolic reprogramming,signal transduction,and epigenetic modifications.Lactylation is a posttranslational modification process induced by lactate,which regulates cellular signaling,gene expression,and protein function,thereby influencing tumor progression.Elevated lactate levels are a key driving factor for lactylation.Tumor-associated macrophage(TAM)in the tumor microenvironment(TME)promote tumor growth,metastasis,and immune evasion.Furthermore,lactate drives polarization of TAM through the lactylation modification mechanism,promotes angiogenesis,and suppresses immune responses,creating a favorable survival environment for tumors.Therefore,this review summarizes the recent research on the regulatory effects of lactate/lactylation on TAM function and its role in tumor treatment,aiming to provide reference for tumor research and treatment.