文献类型：期刊文献

中文题名：LncRNA-MEG3在糖尿病视网膜病变发病机制中的研究进展

英文题名：Research Progress on the Role of LncRNA-MEG3 in the Pathogenesis of Diabetic Retinopathy

作者：郑菀睿[1];罗向霞[2];周茹玉[1];王瑞[1]

第一作者：郑菀睿

机构：[1]甘肃中医药大学,兰州730030;[2]甘肃省中医院,兰州730050

第一机构：甘肃中医药大学

年份：2023

卷号：33

期号：8

起止页码：777

中文期刊名：中国中医眼科杂志

外文期刊名：China Journal of Chinese Ophthalmology

收录：CSTPCD

基金：国家自然科学基金项目(81960888)。

语种：中文

中文关键词：糖尿病视网膜病变;LncRNA-MEG3;微血管病变;长链非编码RNA;炎症

外文关键词：diabetic retinopathy;lncRNA-MEG3;microangiopathy;long noncoding RNA;in?flammation

摘要：糖尿病视网膜病变(DR)是糖尿病最常见的并发症之一,可以引起视网膜损伤、视力下降甚至失明。DR的发病机制尚不明确,其中,长链非编码RNA(lncRNA)以其调节功能而闻名。lncRNA的异常表达可能在DR的发展过程中发挥重要作用,长链非编码RNA母系表达基因3(lncRNA-MEG3)在DR患者血清中低表达,与DR的发生发展关系密切。故本文从微血管稳态、炎症等角度探讨其在DR发病机制中的研究进展,发现促进lncRNA-MEG3表达可调节微血管稳态,抑制炎症反应,在DR进程中扮演重要角色,有望成为DR治疗的新型靶点。
Diabetic retinopathy(DR)is one of the most common complications of diabetes,leading to retinal damage,visual impairment,and even blindness.The pathogenesis of DR is still not fully understood,and long non-coding RNA(lncRNA)has gained recognition for their regula?tory functions.Aberrant expression of lncRNA may play a crucial role in the development of DR,and long non-coding RNA maternally expressed gene 3(lncRNA-MEG3)has been found to be downregulated in the serum of DR patients,closely associated with the occurrence and progression of DR.Therefore,this article explores the research progress of lncRNA-MEG3 in the pathogenesis of DR from the perspectives of microvascular homeostasis,inflammation,and other aspects.It has been discovered that promoting the expression of lncRNA-MEG3 can regulate microvascular ho?meostasis,inhibit inflammatory responses,and play a significant role in the progression of DR,po?tentially serving as a novel target for DR treatment.