文献类型：期刊文献

英文题名：The relationship of nitric oxide synthase 3(NOS3) gene polymorphism in the risk of pulmonary arterial hypertension: A systematic review and meta-analysis

作者：Yi, Kang[1];Guo, Tao[1,2];Wang, Wen-Xin[1];He, Shao-E[2,3];Zhang, Xin[2];Xu, Jian-Guo[2];Wang, Zi-Qiang[1,2];Wang, Fan-Ning[1,2];You, Tao[1,2]

第一作者：Yi, Kang

通信作者：You, T[1]

机构：[1]Gansu Prov Hosp, Dept Cardiovasc Surg, 204 Dong gang West Rd, Lanzhou 730000, Peoples R China;[2]Gansu Int Sci & Technol Cooperat Base Diag & Treat, Lanzhou, Peoples R China; Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China; Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China;[3]Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China; Kangle Cty Lianlu Town Hlth Ctr, Linxia, Gansu, Peoples R China; First Hosp Longnan City, Dept Cardiovasc Surg, Longnan, Peoples R China

第一机构：Gansu Prov Hosp, Dept Cardiovasc Surg, 204 Dong gang West Rd, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Cardiovasc Surg, 204 Dong gang West Rd, Lanzhou 730000, Peoples R China.

年份：2025

卷号：154

起止页码：51

外文期刊名：NITRIC OXIDE-BIOLOGY AND CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85210282344);WOS:【SCI-EXPANDED(收录号:WOS:001371715600001)】；

基金：Health Industry Research Project of Gansu Province of China (GSWSKY-2019-76) ; Medicine Research Fund Project of Gansu Provin-cial Hospital (23GSSYF-30) ; Natural Science Foundation of Gansu Province (22JR5RA655) .

语种：英文

外文关键词：Pulmonary arterial hypertension; Congenital heart disease; Chronic obstructive pulmonary disease; Nitric oxide synthase 3; Single nucleotide polymorphism; Meta-analysis

摘要：Background: We performed the present study to better elucidate the correlation of nitric oxide synthase 3 (NOS3) gene polymorphism with the risk of pulmonary arterial hypertension (PAH). Material/methods: According to the designed search strategy, a systematic literature search was performed through the PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP and Wan Fang databases to collect published case-control studies on the correlation between NOS3 gene polymorphism and PAH. The search deadline was December 26, 2023. Two reviewers independently screened the literature, extracted data and evaluated the quality according to the inclusion and exclusion criteria. Meta-analysis was performed using RevMan 5.4 software. The odds ratio (OR) and 95 % confidence interval (CI) of the genotype distribution were used as the effect indicators. Results: A total of 11 eligible studies were included, involving three single nucleotide polymorphism (SNP) sites of the NOS3 gene: G894T (rs1799983), 4b/4a (rs61722009), and T-786C (rs2070744). The meta-analysis revealed that for PAH analysis, 4 genetic models of NOS3 G894T polymorphism increased the risk of PAH: the allele model (T vs G, OR = 1.9, 95%CI [1.16, 3.11],P = 0.01), the homozygote model (GG vs TT, OR = 1.91, 95%CI [1.04, 3.51], P = 0.04), the heterozygote model (GG vs GT, OR = 3.19, 95%CI [1.65, 6.19], P = 0.0006) and the dominant model (GT + TT vs GG, OR = 3.06, 95%CI [1.54, 6.09], P = 0.001). In the subgroups analysis, the NOS3 G894T polymorphism was found to be associated with the risk of PAH subgroups, including CHD combined with PAH and COPD combined with PAH, Particularly, there is a highly significant correlation with CHD combined with PAH. 2 genetic models of NOS3 4b/4a polymorphism increased the risk of PAH: the homozygote model (BB vs AA, OR = 2.1, 95%CI [1.02, 4.35], P = 0.04) and the recessive model (BB + BA vs AA, OR = 2.55, 95%CI [1.27, 5.11], P = 0.009). In the subgroups analysis, the NOS3 4b/4a polymorphism was found to be associated with the susceptibility of CHD combined with PAH. The results of the combined analysis of each gene model of NOS3 T-786C gene polymorphism sites were not statistically significant, and their P values were all>0.05. The NOS3 G894T and NOS3 4b/4a gene polymorphism had been found to be associated with the risk of PAH in different regional and racial subgroups. In contrast to the NOS3 G894T gene polymorphism, which increased the risk of PAH development in the yellow race subgroup, the NOS3 4b/4a gene polymorphism reduced the risk of PAH development in the white race subgroup and was a protective factor. Conclusions: The NOS3 G894T (rs1799983) and NOS3 4b/4a (rs61722009) gene polymorphism have a strong correlation with the risk of PAH, with this association varying among different regions and ethnicities. However, it is still necessary to expand the sample size and conduct further studies to confirm whether the NOS3 T-786C (rs2070744) polymorphism tends to increase the incidence of PAH.