文献类型：期刊文献

中文题名：重构本草——山楂

英文题名：Reconstruction of Chinese materia medica--hawthorn fruit

作者：姚晨思[1];张伟[1,2];罗金丽[3,4]

第一作者：姚晨思

机构：[1]中国中医科学院广安门医院代谢病研究所,北京100053;[2]甘肃中医药大学基础医学院,兰州730000;[3]广东一方制药有限公司,广东佛山528244;[4]北京中医药大学,北京100029

第一机构：中国中医科学院广安门医院代谢病研究所,北京100053

年份：2023

卷号：43

期号：4

起止页码：455

中文期刊名：吉林中医药

外文期刊名：Jilin Journal of Chinese Medicine

收录：CSTPCD

基金：国家科技创新国际合作重点项目(2021YFE0201100);中国科学院学部咨询评议项目(2021-ZW10-A-017)。

语种：中文

中文关键词：山楂;症靶;标靶;高血脂;消化不良;现代中药;临床回归

外文关键词：hawthorn fruit;symptom target;biochemical indicator target;hyperlipidemia;indigestion;modern Chinese medicine;clinical verifi cation

摘要：中药山楂具有消食健胃,行气散瘀,化浊降脂的功效。综合临床医家应用经验及中药现代药理研究成果认为,山楂的症靶为消化不良、月经不调,标靶为高血脂。此外,山楂及其有效成分还具有促进消化酶分泌、调节胃肠动力、降脂减重、抗动脉粥样硬化、抗心肌缺血和再灌注损伤等作用。山楂的毒性实验显示其无明显不良反应,但脾胃虚弱而无积滞者及胃酸分泌过多者慎用,孕妇不宜过量服用山楂,大量食用山楂会刺激子宫收缩,甚至导致流产。山楂临床经验用量范围为5~30 g,使用本品时当在辨病、辨证的基础上,态靶结合,随症施量。
Hawthorn fruit,a traditional Chinese medicine,has the effects of digesting food,strengthening the stomach,promoting qi and removing blood stasis,resolving turbidity,and reducing fat.Based on the application experience of clinical doctors and the modern pharmacological research results of Chinese materia medica,its symptom targets are believed to be indigestion and irregular menstruation,while its biochemical indicator target is hyperlipidemia.Furthermore,hawthorn fruit and its active ingredients also have the effects of promoting the secretion of digestive enzymes,regulating gastrointestinal motility,reducing fat and weight,anti-atherosclerosis,anti-myocardial ischemia,and resisting the reperfusion injury.The toxicity test of hawthorn fruit shows that it has no obvious toxic or side eff ects,but those with the defi ciency of the spleen and stomach yet no stagnation and those with an excessive gastric acid secretion should use it with caution.Pregnant women should not take too much,otherwise it may stimulate the uterine contraction and even cause an abortion.The clinical experience dosage range of hawthorn fruit is 5-30 g.When it is used in clinic,both the state and the target of a patient should be taken into account and its dosage should be adjusted properly in accordance with the specifi c symptoms on the basis of a disease diff erentiation and a syndrome diff erentiation.