文献类型：期刊文献

英文题名：Biological aging and gout risk in hyperuricemia: a UK Biobank cohort study

作者：Li, Ningfei[1,2];Chen, Zeqi[3];Han, Man[4];Shang, Ao[3];Zhou, Jiayan[5];Sun, Ya Xuan[6];Li, Yige[7];Sun, Jigao[8];Shen, Aling[9];Yang, Yanyu[10];Wei, Benjun[11];Lin, Fei[12];Zhou, Fang[13];Zhu, Xiaoxia[14];Yu, Jing[15];Zhang, Hui[16];Teng, Yuke[17];Bai, Litao[18];Yin, Xiangjun[19];Wu, Ying[20];Li, Jinlin[21];Ayad, Nardeen[22];Cheng, Zhiang[23];Assimes, Themistocles L.[5];Chen, Guang[3,24]

第一作者：Li, Ningfei

通信作者：Chen, G[1]

机构：[1]Guangdong Acad Med Sci, Southern Med Univ, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China;[2]Guangdong Prov Inst Geriatr, Guangzhou, Guangdong, Peoples R China;[3]Univ Hong Kong, Li Ka Shing Fac Med, 3 Sasson Rd,Pok Fu Lam Rd, Hong Kong 999077, Peoples R China;[4]China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol, Beijing, Peoples R China;[5]Stanford Univ, Sch Med, Stanford, CA USA;[6]Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA USA;[7]Harvard Univ, Harvard Med Sch, Dept Hlth Care Policy, Boston, MA USA;[8]Beijing Univ Chinese Med, Dongfang Hosp, Dept Orthoped, Beijing, Peoples R China;[9]Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China;[10]Qinghai Prov Peoples Hosp, Dept Chinese Med, Xining, Qinghai, Peoples R China;[11]Gansu Coll Tradit Chinese Med, Sch Chinese Med, Lanzhou, Peoples R China;[12]Xinxiang Med Univ, Affiliated Hosp 1, Dept Chinese Med, Xinxiang, Henan, Peoples R China;[13]Hubei Hosp Integrated Tradit Chinese & Western Med, Dept Gastroenterol, Wuhan, Peoples R China;[14]Fudan Univ, Huashan Hosp, Div Rheumatol, Shanghai, Peoples R China;[15]Liaoning Univ Tradit Chinese Med, Affiliated Hosp, Div Rheumatol, Shenyang, Liaoning, Peoples R China;[16]Shaanxi Univ Chinese Med, Affiliated Hosp, Dept Neurol, Xian, Peoples R China;[17]Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China;[18]Chongqing Med Univ, Affiliated Hosp 2, Dept Integrated Chinese & Western Med, Chongqing, Peoples R China;[19]Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou, Peoples R China;[20]Harvard Univ, Harvard Law Sch, Cambridge, MA 02138 USA;[21]Harvard Univ, Harvard Kennedy Sch, Cambridge, MA USA;[22]Cairo Univ, Fac Med, Giza, Egypt;[23]Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China;[24]Broad Inst MIT & Harvard, Cambridge, MA USA

第一机构：Guangdong Acad Med Sci, Southern Med Univ, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China

通信机构：[1]corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, 3 Sasson Rd,Pok Fu Lam Rd, Hong Kong 999077, Peoples R China.

年份：2026

卷号：112

期号：2

起止页码：3541

外文期刊名：INTERNATIONAL JOURNAL OF SURGERY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001704518200002)】；

语种：英文

外文关键词：biological aging; disease management; gout; hyperuricemia; prevention; uric acid

摘要：Objective: To investigate the role of biological aging in the progression from hyperuricemia to gout and to evaluate whether an antiaging diet can prevent this progression. Methods: This prospective study involved 412 493 participants from the UK Biobank. Multiple regression models were employed to assess the associations, while Mendelian Randomization was utilized to explore causality. Additionally, the composite dietary antioxidant index (CDAI) was evaluated to examine its preventive effects. Results: Biological aging acceleration was associated with higher level of serum uric acid by an average of 8.1 mu mol/l (95% CI: 7.6-8.7, P < 0.001), 40% increased odds of developing hyperuricemia (OR 1.4, 95% CI: 1.36-1.43, P < 0.001), and 39% increased odds of gout (OR 1.39, 95% CI: 1.32-1.46, P < 0.001). Among the hyperuricemia population, accelerated biological aging participants had a 14% increased odds of developing gout compared with participants with delayed biological aging (OR 1.14, 95% CI 1.06-1.22, P < 0.001). Genetically determined delayed biological aging traits remained significantly causally associated with a decreased risk of gout. Among patients with hyperuricemia, those with positive CDAI had a marginally significant 68% reduction in the odds of developing gout compared to those with negative CDAI (OR 0.32, 95% CI = 0.09-0.96, P = 0.055). Conclusions: These findings suggest that biological aging acceleration represents a risk factor for the progression from hyperuricemia to gout, thus highlighting a new strategy and approach to manage hyperuricemia and prevent gout through healthy aging approaches.