文献类型：期刊文献

英文题名：Jugular Venous Catheterization-Enhanced CT Angiography for In Vivo 3D Visualization of Cardiopulmonary Vasculature in Sprague-Dawley Rats

作者：Gao, Tongtong[1];Liu, Huan[1];He, Jianwei[2];Ma, Like[1];Wu, Mengyu[1];Long, Xiaozhou[2];Cao, Yunshan[3]

第一作者：Gao, Tongtong

通信作者：Long, XZ[1];Cao, YS[2]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Radiol Dept, Lanzhou, Peoples R China;[3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, Chengdu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Radiol Dept, Lanzhou, Peoples R China;[2]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Heart Lung & Vessels Ctr, Chengdu, Peoples R China.

年份：2025

卷号：15

期号：4

外文期刊名：PULMONARY CIRCULATION

收录：;Scopus(收录号：2-s2.0-105019530323);WOS:【SCI-EXPANDED(收录号:WOS:001600090700001)】；

基金：Supported by Lanzhou Science and Technology Program Project Fund (2023-2-55): A study on the clinical application of modified pulmonary vascular CT imaging in pulmonary hypertension.

语种：英文

外文关键词：cardiopulmonary vascular imaging; CT angiography; jugular vein catheterization; Sprague-Dawley rats

摘要：Current in vivo imaging techniques for cardiopulmonary vascular evaluation in Sprague-Dawley (SD) rats face limitations, including structural disruption, inadequate contrast filling, and invasiveness. This study developed a reliable, minimally invasive computed tomography angiography (CTA) technique via jugular vein catheterization for enhanced cardiopulmonary vascular imaging in live SD rats. Jugular vein catheterization was performed in 22 anesthetized healthy male SD rats (320-480 g), followed by dual-source CT angiography with iopamidol contrast. Three-dimensional vascular reconstruction was performed, and pulmonary artery width alongside left and right ventricular diameters was measured. CT-derived measurements were compared with ultrasound data using Bland-Altman analysis. CTA achieved clear visualization of pulmonary arteries, cardiac chambers, and aortic structures, demonstrating complete contrast filling and anatomical detail. Three-dimensional reconstructions precisely delineated mediastinal and vascular relationships. Pulmonary artery widths measured by CT and ultrasound showed strong agreement (p > 0.05), validating reliability. Jugular catheterization enabled stable contrast delivery with minimal trauma. Jugular vein catheterization combined with CT angiography provides a safe, accurate, and minimally invasive method for in vivo cardiopulmonary vascular imaging in SD rats. This technique offers high anatomical resolution, compatibility with hemodynamic assessments, and reduced experimental trauma, establishing this approach as a valuable tool for cardiopulmonary disease model research. CT-derived measurements were compared with ultrasound data using Bland-Altman analysis. CTA achieved clear visualization of cardiac chambers and pulmonary arteries, demonstrating complete contrast filling and anatomical detail. Three-dimensional reconstructions precisely delineated mediastinal and vascular relationships. Pulmonary artery widths measured by CT and ultrasound showed strong agreement (p > 0.05), validating reliability. Jugular catheterization enabled stable contrast delivery with minimal trauma. Jugular vein catheterization combined with CT angiography provides a safe, accurate, and minimally invasive method for in vivo cardiopulmonary vascular imaging in SD rats. This technique offers high anatomical resolution, compatibility with hemodynamic assessments, and reduced experimental trauma, establishing this approach as a valuable tool for cardiopulmonary disease model research.