文献类型：期刊文献

英文题名：Comparison of the pharmacokinetics of Crocin-I in normoxic and hypoxic rats

作者：Wang, Peng[1,2,3];Li, Maoxing[1,2,3,4];Guo, Ziliang[1,3,4];Wang, Weigang[1,2,3];Li, Xiaolin[1,2,3];Yan, Na[4];Liu, Tianlong[1,3]

第一作者：王佩;王萍;Wang, Peng

通信作者：Li, MX[1]

机构：[1]940 Hosp Joint Logist Support Force PLA, Dept Clin Pharm, Lanzhou 730050, Peoples R China;[2]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[3]Gansu Plateau Pharmaceut Technol Ctr, Lanzhou 730050, Peoples R China;[4]Lanzhou Univ, Sch Pharm, Lanzhou 730030, Peoples R China

第一机构：940 Hosp Joint Logist Support Force PLA, Dept Clin Pharm, Lanzhou 730050, Peoples R China

通信机构：[1]corresponding author), 940 Hosp Joint Logist Support Force Chinese Peopl, Dept Clin Pharm, 333 South Binhe Rd, Lanzhou, Peoples R China.

年份：2022

卷号：447

外文期刊名：TOXICOLOGY AND APPLIED PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85131564229);WOS:【SCI-EXPANDED(收录号:WOS:000892864400007)】；

基金：This work was supported by the Logistics Research Project (CLB21J036), the Scientific Research Program of Health Commission in Gansu Province (GSWSKY 2020-41), the Top-notch cultivation project (2021yxky001), the Emergency Medical Research Project of Novel Coronavirus Pneumonia (COVID-19) (20yjky018), and the Youth Development Project (2021yxky060).

语种：英文

外文关键词：Crocin-I; Crocetin; Normoxia; Hypoxia; Pharmacokinetics; UPLC-Q-TOF-MS

摘要：An ultra-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS) method for the simultaneous determination of Crocin-I and its primary metabolites Crocetin was established, and a comparison of metabolic characteristics in vivo is made to Crocin-I and Crocetin in normoxic and hypoxic rats after intragastric administration. The acute hypoxic rat model was established by simulating high altitude environment in a hypobaric hypoxia animal experimental chamber. After intragastric administration of 400 mg.kg(-1) Crocin-I. UPLC-Q-TOF-MS method was used to detect the plasma concentrations of Crocin-I and Crocetin in plasma at different times. Compared with normoxic rats, the area under the curve (AUC), mean residence time (MRT), time to peak (T-max), half-life (T-1/2) and plasma concentration (C-max) of plasma Crocin-I in hypoxic rats were significantly increased (P < 0.01). The apparent distribution (Vz/F) and clearance (CLz/F) of plasma Crocin-I in hypoxic rats were significantly decreased (P < 0.01). Under hypoxic conditions, the pharmacokinetic parameters of Crocin-I and its metabolite Crocetin change significantly. The results provide a theoretical basis for the feasibility of Crocin-I for anti-hypoxia treatment in terms of pharmacokinetics and provide an essential experimental basis for optimizing the drug dosing regimen.