文献类型：期刊文献

中文题名：RAAS与时钟基因的相互作用及其在心血管疾病研究中作用的进展

英文题名：Research progress of the interaction between RAAS and clock genes in cardiovascular diseases

作者：马睿玲[1];王怡园[1];寇雨顺[1];沈路凡[1];王鸿[1];张玲娜[1];田皎[1];伊琳[1,2]

第一作者：马睿玲

机构：[1]甘肃中医药大学中西医结合学院,兰州730000;[2]甘肃省中医药防治慢性疾病重点实验室,兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2025

卷号：77

期号：4

起止页码：669

中文期刊名：生理学报

外文期刊名：Acta Physiologica Sinica

收录：;北大核心:【北大核心2023】；

基金：supported by the National Natural Science Foundation of China (No. 82160842);the General Project of the Gansu Provincial Joint Research Fund (No. 23JRRA1521);the Gansu Provincial Natural Science Foundation Project (No. 24JRRA1019);the Innovation Fund for University Teachers of the Gansu Provincial Department of Education (No. 2023A-083)。

语种：中文

中文关键词：肾素-血管紧张素-醛固酮系统;时钟基因;生物节律;心血管疾病

外文关键词：renin-angiotensin-aldosterone system;clock genes;biological rhythms;cardiovascular diseases

摘要：肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)在调节血压和维持体液平衡方面具有重要的生理功能,而时钟基因则是保持生物节律和调控代谢的关键因素。RAAS与时钟基因之间存在复杂的交互关系,这种关系可能在多种心血管疾病和代谢性疾病的发生和发展中起着重要作用。尽管已有文献揭示了RAAS与时钟基因之间的相关性,但对二者相互作用的具体机制尚理解不足,且在不同生理和病理状态下的交互模式亟需进一步探讨。本文综述RAAS与时钟基因在心血管疾病中的协同作用,探讨其分子机制、病理生理联系及时辰治疗学的应用及未来研究的潜在方向,以期为相关疾病的预防和治疗提供新的见解。
The renin-angiotensin-aldosterone system(RAAS)is crucial for regulating blood pressure and maintaining fluid balance,while clock genes are essential for sustaining biological rhythms and regulating metabolism.There exists a complex interplay between RAAS and clock genes that may significantly contribute to the development of various cardiovascular and metabolic diseases.Although current literature has identified correlations between these two systems,the specific mechanisms of their interaction remain unclear.Moreover,the interaction patterns under different physiological and pathological conditions need further investigation.This review summarizes the synergistic roles of the RAAS and clock genes in cardiovascular diseases,explores their molecular mechanisms and pathophysiological connections,discusses the application of chronotherapy,and highlights potential future research directions,aiming to provide novel insights for the prevention and treatment of related diseases.