文献类型：期刊文献

英文题名：The clinical effectiveness of traditional Chinese medicine in treating diabetes-related pruritus: a systematic review and meta-analysis

作者：Sui, Yan[1];Wei, Kongxi[1];Du, Jinping[1];Liu, Yanping[2];Zhang, Qiang[3];Zhang, Ru[1]

第一作者：Sui, Yan

通信作者：Zhang, R[1]

机构：[1]Baiyin First Peoples Hosp, Dept Dermatol, Baiyin 730900, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Dermatol, Lanzhou 730000, Gansu, Peoples R China;[3]Baiyin First Peoples Hosp, Dept Sci & Educ, Baiyin 730900, Gansu, Peoples R China

第一机构：Baiyin First Peoples Hosp, Dept Dermatol, Baiyin 730900, Gansu, Peoples R China

通信机构：[1]corresponding author), Baiyin First Peoples Hosp, Dept Dermatol, Baiyin 730900, Gansu, Peoples R China.

年份：2026

卷号：36

期号：3

起止页码：256

外文期刊名：EUROPEAN JOURNAL OF DERMATOLOGY

收录：;Scopus(收录号：2-s2.0-105046149554);WOS:【SCI-EXPANDED(收录号:WOS:001848309100005)】；

基金：Funding: Gansu Provincial Department of Education Higher Education Innovation Project (2021B-167)

语种：英文

外文关键词：diabetic; pruritus; traditional Chinese medicine

摘要：Background: Traditional Chinese medicine (TCM) has been increasingly applied in treating diabetic pruritus. Objectives: To conduct a systematic review and meta-analysis evaluating the efficacy and safety of TCM or integrated TCM-Western therapy for diabetic pruritus. Materials & Methods: This systematic review and meta-analysis was registered with registration number: INPLASY202570074. Major Chinese and international databases (China National Knowledge Infrastructure, PubMed, Web of Science and ScienceDirect) were searched between their inception and December 2024. Eligible randomised controlled trials (RCTs) investigating TCM or integrated TCM-Western therapies for diabetic pruritus were included. Two independent researchers performed literature screening, data extraction and quality assessment according to predefined inclusion and exclusion criteria. Outcome indicators included clinical efficacy rate, pruritus severity (Visual Analogue Scale [VAS] score) and incidence of adverse reactions. Meta-analyses were conducted using RevMan 5.4, Stata 16.0 or R 4.x. Results: A total of 13 RCTs were included, with 557 participants in both the control group and the experimental group. Meta-analysis showed that TCM or integrated TCM-Western therapies significantly improved clinical efficacy compared with control groups (risk ratio [RR]=1.30, 95% CI:1.17-1.45, p<0.001). Most studies favoured TCM or integrated therapy in reducing VAS scores. Pooled estimate (mean difference=-1.09, 95% CI: -2.20-0.03, p=0.06) did not reach statistical significance due to high heterogeneity (I2=92.8%), indicating substantial variability among studies. Conclusion: Despite the heterogeneity, the existing evidence suggests that TCM or integrated TCM-Western therapies have potential clinical advantages in treating diabetic pruritus, including improved efficacy and lower incidence of adverse reactions.