文献类型：期刊文献

英文题名：Enhanced the corrosion resistance and biocompatibility of magnesium alloy by hydroxyapatite composite coating of AZ31/Ti/PDA/HA

作者：Zhang, Guangwen[1];Xu, Yimeng[2];Zeng, Zhaoyang[1];Cao, Baocheng[2]

第一作者：张广文

通信作者：Cao, BC[1]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China;[2]Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China.

年份：2021

卷号：9

期号：2

外文期刊名：SURFACE TOPOGRAPHY-METROLOGY AND PROPERTIES

收录：;EI(收录号：20212710594721);Scopus(收录号：2-s2.0-85109112532);WOS:【SCI-EXPANDED(收录号:WOS:000664730100001)】；

语种：英文

外文关键词：magnesium alloy; Ti ion implantation; biomimetic mineralization; hydroxyapatite; cell compatibility; corrosion resistance

摘要：A series of hydroxyapatite (HA) composite coatings of AZ31/HA, AZ31/PDA/HA, AZ31/Ti/HA, AZ31/Ti/PDA/HA were successfully fabricated combinedwith Ti ion implantation and Polydopamine (PDA). The SEM and EDS results showed that the AZ31/Ti/PDA/HA composite coating with a petal-like structure is more uniform and compact and the calcium-phosphorus ratio of AZ31/Ti/PDA/HA coating is 1.65, which is closer to the theoretical percentage of calcium-phosphorus in the hydroxyapatite of 1.67 compared to the other HA coatings. In addition, AZ31/Ti/PDA/HA coating exhibits best corrosion resistance, including the highest corrosion potential, lowest corrosion current and slowest amount of hydrogen evolution. The results of the MTT experiment showed that MC3T3-E1 cells presented a dendritic structure with no mitotic phase. The results of cell proliferation experiment showed that the cell proliferation rate of AZ31/PDA/HA, AZ31/Ti/HA, AZ31/Ti/PDA/HA group were higher than that of the negative control group except AZ31 substrate and AZ31/HA group. The 7-day cell proliferation rate of the AZ31/Ti/PDA/HA coating group was higher than those of the other groups. The AKP test showed that the ALP activity of the AZ31/Ti/PDA/HA coating group is strongest than other groups. Alizarin red staining results showed that the calcium nodules of the AZ31/Ti/PDA/HA coating group had the deepest staining and the highest density, which indicated that synergistic osteogenic ability of each component of composite coating was the best.