文献类型：期刊文献

中文题名：miR-126在糖尿病视网膜病变发病机制及诊疗应用中的作用研究进展

英文题名：The progress on the role of miR-126 in the pathogenesis, diagnosis and treatment of diabetic retinopathy

作者：王瑞[1];罗向霞[2];胡婷婷[1];张钰洁[1]

第一作者：王瑞

机构：[1]甘肃中医药大学中医临床学院,兰州750000;[2]甘肃省中医院眼科,兰州730050

第一机构：甘肃中医药大学中医临床学院

年份：2021

卷号：37

期号：11

起止页码：906

中文期刊名：中华眼底病杂志

外文期刊名：Chinese Journal of Ocular Fundus Diseases

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金(81960888);2019年甘肃中医药大学研究生创新基金(2020CX03);甘肃省教育厅2021年度优秀研究生"创新之星"项目(2021CXZX-767)。

语种：中文

中文关键词：糖尿病视网膜病变;微血管;综述;miR-126

外文关键词：Diabetic retinopathy;Microvessels;Review;miR-126

摘要：微血管功能障碍是糖尿病视网膜病变(DR)的关键病理机制。近年来研究发现,糖尿病患者普遍存在"代谢记忆"现象,即使其血糖控制良好,也无法避免糖尿病微血管病变。因此,从基因角度来探索DR的发病机制非常必要。miR-126是血管内皮细胞唯一特异性表达的microRNA,与新生血管的形成关系密切,可影响DR微血管的稳定性及内皮细胞的萌芽和迁移,且其基因水平与血管内皮细胞生长因子的表达呈显著负相关。细胞内和循环中的miR-126在DR微血管稳态调节、早期诊疗和病程监测等方面的潜在价值受到了极大的关注,但这一领域的研究报道多以假说为驱动,仍有一定局限性。相信随着基因组学的快速发展,miRNA谱及其在眼发育和眼部疾病中的分子机制将会逐渐清晰,未来可能会在个别难治性视网膜疾病的干预中率先获得突破,建立一种新型的miRNA诊疗手段。
Microvascular dysfunction is a key pathological mechanism of diabetic retinopathy(DR).In recent years,it has been found that the phenomenon of"metabolic memory"is prevalent in diabetic patients,and diabetic microangiopaplasia cannot be avoided even if patients'blood glucose is well controlled.Therefore,it is necessary to explore DR from a genetic perspective.miR-126 is the unique microRNA specifically expressed in vascular endothelial cells,which is closely related to the formation of neovascularization and can affect the stability of DR microvessels as well as the germination and migration of endothelial cells,and its gene level is significantly negatively correlated with the expression of vascular endothelial cell growth factor.The potential value of intracellular and circulating miR-126 in the regulation of DR microvascular homeostasis,early diagnosis and treatment,and monitoring of disease course has attracted great attention.However,studies in this area are mostly hypothesis-driven and still have some limitations.It is believed that with the rapid development of genomics,the miRNA spectrum and its molecular mechanism in eye development and eye diseases will gradually become clear,which may lead to a breakthrough in the intervention of individual refractory retinal diseases and establish a new miRNA diagnosis and treatment method in the future.