文献类型：期刊文献

英文题名：Therapeutic effect of angelica and its compound formulas for hypertension and the complications: Evidence mapping

作者：Wei Huiping[1,2,3,4];Xiao Yujie[5];Tong Yajing[6];Chen Yaolong[7,8,9];Luo Xufei[7,8,9];Wang Yu[2,5];Jin Pei[2];Ma Chengxu[1,4];Fu Zhaoyuan[1,2,3,4];Guo Huan[1,4];Zhao Xinke[1,2,3,4];Li Yingdong[1,3,4]

第一作者：魏惠平;Wei Huiping

通信作者：Li, YD[1];Li, YD[2];Li, YD[3]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Inst Integrated Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[4]Key Lab Tradit Chinese Med Prevent & Treatment Ch, Lanzhou 730000, Gansu, Peoples R China;[5]Lanzhou Univ, Med Sch 2, Lanzhou 730000, Gansu, Peoples R China;[6]Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[7]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China;[8]Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou 730000, Gansu, Peoples R China;[9]WHO Collaborating Ctr Guideline Implementat & Kno, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Inst Integrated Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Key Lab Tradit Chinese Med Prevent & Treatment Ch, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2019

卷号：59

外文期刊名：PHYTOMEDICINE

收录：;Scopus(收录号：2-s2.0-85065517340);WOS:【SCI-EXPANDED(收录号:WOS:000473048600007)】；

基金：This research supported by the National Natural Science Foundation of China (Grant No. 81873132), and the Transformation and Cultivation Project Plan of Scientific Achievements in Universities (Gansu Education Department, No. 2016D-11).

语种：英文

外文关键词：Angelica; Hypertension; Evidence mapping; Traditional Chinese medicine

摘要：Background: Hypertension is one of the common diseases, which brings heavy burden to human race. Currently, western medication is in absolutely dominant position in the treatment of hypertension, but it maintains for a short time and there are various side effects and drug tolerance. Therefore, Chinese medicine has attracted great attention in the treatment field of hypertension, and angelica is one of the most frequently used herbs. Objectives: In order to give some inspiration to researches in these fields, this article presents the current research status of angelica and its compound formulas treating hypertension and its complications with evidence mapping. Methods: Main databases were systematically searched, and researches about angelica or its compound formulas containing angelica treating hypertension or its complications were included. EXCEL 2013 was used to integrate and process the data, and the result is showed intuitively with the bubble diagram. Results: 49 RCTs were included after screening. The articles recruited were published with a rising trend along with time. Of the 49 RCTs, there is the outcome measure of general the efficacy in the result part in 34 RCTs (69.4%), and group. There is the outcome measure of reduction of MAP in the result part in 28 RCTs, and 27 RCTs (96.4%) showed that the angelica intervention group is significantly improved than the control group while 1 (3.6%) showed no significant differences. There is the outcome measure of efficacy of target organ protection in the result part in 26 RCTs, and 25 RCTs (96.2%) showed that there is significant difference between the angelica intervention group and the control group. Of the 49 RCTs, there is the outcome measure of adverse effects in the result part in 17 RCTs. 14 RCTs (82.4%) reported no adverse effects, 2 RCTs (11.8%) reported adverse effects rate as lower than 10%, and 1 RCT (7.1%) reported adverse effects rate as higher than 40%. Conclusion: Current research with low quality has revealed that angelica is effective in reduction of MAP and target organ protection and the adverse effects rate is low, and the effectiveness and safety of angelica needs to be proved by further researches with high quality. Researches of high quality are needed to provide scientific evidence for angelica in treating hypertension and its complications.