详细信息
表观遗传在骨质疏松症中的作用及针灸干预临床研究进展
The role of epigenetics in osteoporosis and clinical research progress in acupuncture intervention
文献类型:期刊文献
中文题名:表观遗传在骨质疏松症中的作用及针灸干预临床研究进展
英文题名:The role of epigenetics in osteoporosis and clinical research progress in acupuncture intervention
作者:滕润霞[1];魏清琳[2];邹昕宇[1];樊佳煊[1];汪军强[2];席金梦[1]
第一作者:滕润霞
机构:[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000
第一机构:甘肃中医药大学
年份:2025
卷号:31
期号:8
起止页码:1243
中文期刊名:中国骨质疏松杂志
外文期刊名:Chinese Journal of Osteoporosis
收录:;北大核心:【北大核心2023】;
基金:甘肃省皇甫谧针灸医院科研孵化项目(ZJKF2201)。
语种:中文
中文关键词:表观遗传学;骨质疏松症;针灸;机制
外文关键词:epigenetics;osteoporosis;acupuncture;mechanism
摘要:表观遗传学是在不改变DNA序列的情况下改变基因表达,调节成骨与破骨细胞的分化,进而参与骨质疏松症(osteoporosis,OP)的发生发展,其包括DNA甲基化、组蛋白修饰和非编码RNA(ncRNA),然其机制尚未完全明确。此外,针灸治疗OP疗效确切,安全性高,该文综述了OP的表观遗传学机制研究,归纳总结针灸靶向调控表观遗传学防治OP的临床研究成果,以期为OP的机制研究及针灸对OP的临床治疗提供理论依据和新思路。
Epigenetics is to change gene expression without changing the DNA sequence,regulates the differentiation of osteoblasts and osteoclasts,and then participates in the occurrence and development of osteoporosis(OP).It includes DNA methylation,histone modification,and non-coding RNA(ncRNA).However,its mechanism is not yet fully understood.In addition,acupuncture and moxibustion are effective and safe in the treatment of OP.This paper reviews the epigenetic mechanism of OP and summarizes the clinical research result of acupuncture and moxibustion targeting regulation of epigenetic prevention and treatment of OP,in order to provide theoretical basis and new ideas for the mechanism research of OP and the clinical treatment of OP with acupuncture and moxibustion.
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